Effect of serotonin and thromboxane A2 on blood flow through moderately well developed coronary collateral vessels
L Wright,
DC Homans,
DD Laxson,
XZ Dai,
and
RJ Bache
Department of Medicine, University of Minnesota Medical School, Minneapolis.
This study was performed to determine whether thromboxane A2 (as the analogue U46619) and serotonin can cause vasoconstriction of moderately well developed coronary collateral vessels. Studies were carried out in seven adult mongrel dogs 2 to 4 months after embolic occlusion of the left anterior descending coronary artery had been performed to stimulate collateral vessel growth. At the time of study this artery was cannulated to determine interarterial collateral flow from measurements of retrograde blood flow. Radioactive microspheres were administered during retrograde flow collection to determine continuing tissue flow for evaluation of microvascular collateral communications. Serotonin (50 micrograms/min) resulted in a 48 +/- 11% decrease in retrograde flow (p less than 0.01), with a 36 +/- 10% decrease in total collateral blood flow (p less than 0.02). Infusion of U46619 (0.01 microgram/kg per min) caused a 38 +/- 13% decrease in retrograde blood flow (p less than 0.01), with a 34 +/- 13% decrease in total collateral flow (p less than 0.05). Serotonin caused a significant increase in tissue flow to the subepicardium of the collateral-dependent region, whereas U46619 caused no change in tissue blood flow. These data demonstrate that both serotonin and thromboxane A2 can cause vasoconstriction of interarterial coronary collateral vessels. The findings suggest that platelet activation in coronary arteries from which collateral vessels originate has potential for causing collateral vasoconstriction, thereby compromising blood flow to the dependent myocardium.
This article has been cited by other articles:

|
 |

|
 |
 
D. J. Duncker and R. J. Bache
Regulation of Coronary Blood Flow During Exercise
Physiol Rev,
July 1, 2008;
88(3):
1009 - 1086.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M Mansaray, J.W Hynd, I Vergroesen, P.R Belcher, A.J Drake-Holland, and M.I.M Noble
Measurement of coronary collateral flow and resistance in the presence of an open critical stenosis, and the response to intra-arterial thrombosis
Cardiovasc Res,
August 1, 2000;
47(2):
359 - 366.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Tanaka, M. Fujita, I. Nakae, S.-I. Tamaki, K. Hasegawa, Y. Kihara, R. Nohara, and S. Sasayama
Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina
J. Am. Coll. Cardiol.,
December 1, 1998;
32(7):
1982 - 1986.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. W. Kinn and R. J. Bache
Effect of Platelet Activation on Coronary Collateral Blood Flow
Circulation,
October 6, 1998;
98(14):
1431 - 1437.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. A. Rapps, A. W. Jones, M. Sturek, L. Magliola, and J. L. Parker
Mechanisms of Altered Contractile Responses to Vasopressin and Endothelin in Canine Coronary Collateral Arteries
Circulation,
January 7, 1997;
95(1):
231 - 239.
[Abstract]
[Full Text]
|
 |
|
|