On-line assessment of ventricular function by automatic boundary detection and ultrasonic backscatter imaging

Cardiovascular Division, Washington University, St. Louis, Missouri.

To provide an approach suitable for on-line analysis of ventricular function, a conventional two-dimensional ultrasound imaging system was modified to detect and track blood-tissue interfaces in real time based on their quantitative acoustic properties. This modification permitted on-line display of the left ventricular cavity area, fractional area change, volumes and ejection fraction on a beat by beat basis. Images were obtained from 54 patients and 12 normal subjects with broad ranges of ventricular dimensions and systolic function. On-line measurements of cavity areas were compared with off-line measurements of cavity areas (analysis of videotaped conventional images). Left ventricular cavity areas measured on-line from short-axis views correlated closely with off-line views as did areas from apical views. On-line fractional area change correlated well with ejection fraction calculated off-line. More than 70% of patients could be studied adequately with the approach developed. Thus, automatic boundary detection based on quantitative assessment of tissue acoustic properties permits on-line quantitation of ventricular cavity areas and indexes of function.

This article has been cited by other articles:

				M. Cannesson, M. Tanabe, M. S. Suffoletto, D. M. McNamara, S. Madan, J. M. Lacomis, and J. Gorcsan III A Novel Two-Dimensional Echocardiographic Image Analysis System Using Artificial Intelligence-Learned Pattern Recognition for Rapid Automated Ejection Fraction J. Am. Coll. Cardiol., January 16, 2007; 49(2): 217 - 226. [Abstract] [Full Text] [PDF]

				J. J. Gavira, J. Herreros, A. Perez, M. J. Garcia-Velloso, J. Barba, F. Martin-Herrero, C. Canizo, A. Martin-Arnau, J. M. Marti-Climent, M. Hernandez, et al. Autologous skeletal myoblast transplantation in patients with nonacute myocardial infarction: 1-year follow-up J. Thorac. Cardiovasc. Surg., April 1, 2006; 131(4): 799 - 804. [Abstract] [Full Text] [PDF]

				J. Herreros, F. Prosper, A. Perez, J. J Gavira, M. J. Garcia-Velloso, J. Barba, P. L Sanchez, C. Canizo, G. Rabago, J. M Marti-Climent, et al. Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction Eur. Heart J., November 2, 2003; 24(22): 2012 - 2020. [Abstract] [Full Text] [PDF]

				N. L. Greenberg, M. S. Firstenberg, P. L. Castro, M. Main, A. Travaglini, J. A. Odabashian, J. K. Drinko, L. L. Rodriguez, J. D. Thomas, and M. J. Garcia Doppler-Derived Myocardial Systolic Strain Rate Is a Strong Index of Left Ventricular Contractility Circulation, January 1, 2002; 105(1): 99 - 105. [Abstract] [Full Text] [PDF]

				H. Senzaki, C.-H. Chen, S. Masutani, M. Taketazu, J. Kobayashi, T. Kobayashi, N. Sasaki, H. Asano, S. Kyo, and Y. Yokote Assessment of cardiovascular dynamics by pressure-area relations in pediatric patients with congenital heart disease J. Thorac. Cardiovasc. Surg., September 1, 2001; 122(3): 535 - 547. [Abstract] [Full Text] [PDF]

				A. Y. Denault, J. Gorcsan III, and M. R. Pinsky Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations J Appl Physiol, July 1, 2001; 91(1): 298 - 308. [Abstract] [Full Text] [PDF]

				M. V. T. Tantengco, R. L. Thomas, and P. P. Karpawich Left ventricular dysfunction after long-term right ventricular apical pacing in the young J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2093 - 2100. [Abstract] [Full Text] [PDF]

				B. P. Cholley, R. M. Lang, C. E. Korcarz, and S. G. Shroff Smooth muscle relaxation and local hydraulic impedance properties of the aorta J Appl Physiol, June 1, 2001; 90(6): 2427 - 2438. [Abstract] [Full Text] [PDF]

				V. Mor-Avi, K. Spencer, J. Gorcsan, A. Demaria, T. Kimball, M. Monaghan, J. Perez, J. P. Sun, L. Weinert, J. Bednarz, et al. Normal values of regional left ventricular endocardial motion: multicenter color kinesis study Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2464 - H2476. [Abstract] [Full Text] [PDF]

				R. Koch, R. M. Lang, M.-J. Garcia, L. Weinert, J. Bednarz, C. Korcarz, B. Coughlan, A. Spiegel, E. Kaji, K. T. Spencer, et al. Objective evaluation of regional left ventricular wall motion during dobutamine stress echocardiographic studies using segmental analysis of color kinesis images J. Am. Coll. Cardiol., August 1, 1999; 34(2): 409 - 419. [Abstract] [Full Text] [PDF]

				A. Y. Denault, T. A. Gasior, J. Gorcsan III, W. A. Mandarino, L. G. Deneault, and M. R. Pinsky Determinants of Aortic Pressure Variation During Positive-Pressure Ventilation in Man Chest, July 1, 1999; 116(1): 176 - 186. [Abstract] [Full Text] [PDF]

				P. VIGNON, L. WEINERT, V. MOR-AVI, K. T. SPENCER, J. BEDNARZ, and R. M. LANG Quantitative Assessment of Regional Right Ventricular Function with Color Kinesis Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1949 - 1959. [Abstract] [Full Text]

				J. Garot, G.A. Derumeaux, J.L. Monin, A.M. Duval-Moulin, M. Simon, D. Pascal, A. Castaigne, J.L. Dubois-Rande, B. Diebold, and P. Gueret Quantitative systolic and diastolic transmyocardial velocity gradients assessed by M-mode colour Doppler tissue imaging as reliable indicators of regional left ventricular function after acute myocardial infarction Eur. Heart J., April 2, 1999; 20(8): 593 - 603. [Abstract] [PDF]

				Y. Ochiai, S. Morita, Y. Tanoue, Y. Kawachi, R. Tominaga, and H. Yasui Use of transesophageal echocardiography for postoperative evaluation of right ventricular function Ann. Thorac. Surg., January 1, 1999; 67(1): 146 - 152. [Abstract] [Full Text] [PDF]

				T. Geva, A. J. Powell, E. C. Crawford, T. Chung, and S. D. Colan Evaluation of Regional Differences in Right Ventricular Systolic Function by Acoustic Quantification Echocardiography and Cine Magnetic Resonance Imaging Circulation, July 28, 1998; 98(4): 339 - 345. [Abstract] [Full Text] [PDF]

				G. Derumeaux, M. Ovize, J. Loufoua, X. Andre-Fouet, Y. Minaire, A. Cribier, and B. Letac Doppler Tissue Imaging Quantitates Regional Wall Motion During Myocardial Ischemia and Reperfusion Circulation, May 19, 1998; 97(19): 1970 - 1977. [Abstract] [Full Text] [PDF]

				J. Gorcsan III, D. P. Strum, W. A. Mandarino, V. K. Gulati, and M. R. Pinsky Quantitative Assessment of Alterations in Regional Left Ventricular Contractility With Color-Coded Tissue Doppler Echocardiography : Comparison With Sonomicrometry and Pressure-Volume Relations Circulation, May 20, 1997; 95(10): 2423 - 2433. [Abstract] [Full Text]

				V. Mor-Avi, P. Vignon, R. Koch, L. Weinert, M. J. Garcia, K. T. Spencer, and R. M. Lang Segmental Analysis of Color Kinesis Images : New Method for Quantification of the Magnitude and Timing of Endocardial Motion During Left Ventricular Systole and Diastole Circulation, April 15, 1997; 95(8): 2082 - 2097. [Abstract] [Full Text]

				W. A. Mandarino, S. Winowich, J. Gorcsan III, T. A. Gasior, S. M. Pham, B. P. Griffith, and R. L. Kormos Right Ventricular Performance and Left Ventricular Assist Device Filling Ann. Thorac. Surg., April 1, 1997; 63(4): 1044 - 1049. [Abstract] [Full Text]

				E. K. Louie and D. S. Louie New Echocardiographic Technology: Does it Add to Clinical Decision-Making? Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1997; 1(1): 16 - 31. [PDF]

				J. Gorcsan III, S. Murali, P. J. Counihan, W. A. Mandarino, and R. L. Kormos Right Ventricular Performance and Contractile Reserve in Patients With Severe Heart Failure: Assessment by Pressure-Area Relations and Association With Outcome Circulation, December 15, 1996; 94(12): 3190 - 3197. [Abstract] [Full Text]

				R. M. Lang, P. Vignon, L. Weinert, J. Bednarz, C. Korcarz, J. Sandelski RDMS, R. Koch, D. Prater, and V. Mor-Avi Echocardiographic Quantification of Regional Left Ventricular Wall Motion With Color Kinesis Circulation, May 15, 1996; 93(10): 1877 - 1885. [Abstract] [Full Text]

				M. Oe, J. Gorcsan III, W. A. Mandarino, A. Kawai, B. P. Griffith, and R. L. Kormos Automated Echocardiographic Measures of Right Ventricular Area as an Index of Volume and End-Systolic Pressure-Area Relations to Assess Right Ventricular Function Circulation, August 15, 1995; 92(4): 1026 - 1033. [Abstract] [Full Text]

				S. Cullen, D. Shore, and A. Redington Characterization of Right Ventricular Diastolic Performance After Complete Repair of Tetralogy of Fallot : Restrictive Physiology Predicts Slow Postoperative Recovery Circulation, March 15, 1995; 91(6): 1782 - 1789. [Abstract] [Full Text]

				A. D. Waggoner, V. G. Davila-Roman, B. Barzilai, J. G. Miller, and J. E. Perez Quantitative Echocardiography, Part 2: Automatic Boundary Detection for On-line Assessment of Left Ventricular and Atrial Function Journal of Diagnostic Medical Sonography, March 1, 1994; 10(2): 95 - 103. [Abstract] [PDF]

				E. A Hessel II Review article : What's new in monitoring the coronary surgery patient? Perfusion, July 1, 1992; 7(3): 161 - 194. [Abstract] [PDF]