JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
 QUICK SEARCH:   [advanced]


     


J Am Coll Cardiol, 1991; 18:1617-1626
© 1991 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lieberman, E.
Right arrow Articles by Baughman, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lieberman, E.
Right arrow Articles by Baughman, K.

Clinicopathologic description of myocarditis

EB Lieberman, GM Hutchins, A Herskowitz, NR Rose, and KL Baughman

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Histologic evidence of myocarditis was demonstrated in 35 of 348 patients submitted to endomyocardial biopsy over 5 years. Analysis of the histologic findings and clinical course of these patients resulted in a new clinicopathologic classification of myocarditis in which four distinct subgroups are identified. Patients with fulminant myocarditis become acutely ill after a distinct viral prodrome, have severe cardiovascular compromise, multiple foci of active myocarditis by histologic study and ventricular dysfunction that either resolves spontaneously or results in death. Patients with acute, chronic active and chronic persistent myocarditis have a less distinct onset of illness. Patients with acute myocarditis present with established ventricular dysfunction and may respond to immunosuppressive therapy or their condition may progress to dilated cardiomyopathy. Those with chronic active myocarditis initially respond to immunosuppressive therapy, but they have clinical and histologic relapses and develop ventricular dysfunction associated with chronic inflammatory changes including giant cells on histologic study. Chronic persistent myocarditis is characterized by a persistent histologic infiltrate, often with foci of myocyte necrosis but without ventricular dysfunction despite other cardiovascular symptoms such as chest pain or palpitation.


This article has been cited by other articles:


Home page
NEJMHome page
M. S. Sabatine, K.-K. Poh, J. L. Mega, J.-A. O. Shepard, J. R. Stone, and M. P. Frosch
Case 36-2007 -- A 31-Year-Old Woman with Rash, Fever, and Hypotension
N. Engl. J. Med., November 22, 2007; 357(21): 2167 - 2178.
[Full Text] [PDF]


Home page
CirculationHome page
H. Mahrholdt, A. Wagner, C. C. Deluigi, E. Kispert, S. Hager, G. Meinhardt, H. Vogelsberg, P. Fritz, J. Dippon, C. -T. Bock, et al.
Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis
Circulation, October 10, 2006; 114(15): 1581 - 1590.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
N Amabile, A Fraisse, J Bouvenot, P Chetaille, and C Ovaert
Outcome of acute fulminant myocarditis in children
Heart, September 1, 2006; 92(9): 1269 - 1273.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
J. W. Magnani and G. W. Dec
Myocarditis: Current Trends in Diagnosis and Treatment
Circulation, February 14, 2006; 113(6): 876 - 890.
[Full Text] [PDF]


Home page
CirculationHome page
K. L. Baughman
Diagnosis of Myocarditis: Death of Dallas Criteria
Circulation, January 31, 2006; 113(4): 593 - 595.
[Full Text] [PDF]


Home page
Eur Heart JHome page
Y. Asaumi, S. Yasuda, I. Morii, H. Kakuchi, Y. Otsuka, A. Kawamura, Y. Sasako, T. Nakatani, H. Nonogi, and S. Miyazaki
Favourable clinical outcome in patients with cardiogenic shock due to fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenation
Eur. Heart J., October 2, 2005; 26(20): 2185 - 2192.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
H. Abdel-Aty, P. Boye, A. Zagrosek, R. Wassmuth, A. Kumar, D. Messroghli, P. Bock, R. Dietz, M. G. Friedrich, and J. Schulz-Menger
Diagnostic Performance of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis: Comparison of Different Approaches
J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1815 - 1822.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
Y.-S. Chen and H.-Y. Yu
Choice of mechanical support for fulminant myocarditis: ECMO vs. VAD?
Eur. J. Cardiothorac. Surg., May 1, 2005; 27(5): 931 - 932.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
B. J. Maron, M. J. Ackerman, R. A. Nishimura, R. E. Pyeritz, J. A. Towbin, and J. E. Udelson
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome
J. Am. Coll. Cardiol., April 19, 2005; 45(8): 1340 - 1345.
[Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
J.-M. Grinda, P. Chevalier, N. D'Attellis, M.-O. Bricourt, A. Berrebi, P. Guibourt, J.-N. Fabiani, and A. Deloche
Fulminant myocarditis in adults and children: bi-ventricular assist device for recovery
Eur. J. Cardiothorac. Surg., December 1, 2004; 26(6): 1169 - 1173.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
M. Nishii, T. Inomata, H. Takehana, I. Takeuchi, H. Nakano, T. Koitabashi, J.-i. Nakahata, N. Aoyama, and T. Izumi
Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis
J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1292 - 1297.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
K. U. Knowlton and T. Yajima
Interleukin-10: Biomarker or pathologic cytokine in fulminant myocarditis?
J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1298 - 1300.
[Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
P. Leprince, A. Combes, N. Bonnet, A. Ouattara, C. E. Luyt, P. Theodore, P. Leger, and A. Pavie
Circulatory support for fulminant myocarditis: consideration for implantation, weaning and explantation
Eur. J. Cardiothorac. Surg., September 1, 2003; 24(3): 399 - 403.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
J.M. Hare and K.L. Baughman
Fulminant and acute lymphocytic myocarditis: the prognostic value of clinicopathological classification
Eur. Heart J., February 2, 2001; 22(4): 269 - 270.
[PDF]


Home page
CirculationHome page
K. Fuse, M. Kodama, Y. Okura, M. Ito, S. Hirono, K. Kato, H. Hanawa, and Y. Aizawa
Predictors of Disease Course in Patients With Acute Myocarditis
Circulation, December 5, 2000; 102(23): 2829 - 2835.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
A. M. Feldman and D. McNamara
Myocarditis
N. Engl. J. Med., November 9, 2000; 343(19): 1388 - 1398.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
G. M. Felker, J. P. Boehmer, R. H. Hruban, G. M. Hutchins, E. K. Kasper, K. L. Baughman, and J. M. Hare
Echocardiographic findings in fulminant and acute myocarditis
J. Am. Coll. Cardiol., July 1, 2000; 36(1): 227 - 232.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
R. E. McCarthy, J. P. Boehmer, R. H. Hruban, G. M. Hutchins, E. K. Kasper, J. M. Hare, and K. L. Baughman
Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis
N. Engl. J. Med., March 9, 2000; 342(10): 690 - 695.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
J. S. Karliner
Fulminant Myocarditis
N. Engl. J. Med., March 9, 2000; 342(10): 734 - 735.
[Full Text]


Home page
Arch Intern MedHome page
G. M. Hutchins, R. Hanzlick, and and the Autopsy Committee of the College of Americ
Case of the Month: Speculation and Competing Causes of Death
Arch Intern Med, August 10, 1998; 158(15): 1593 - 1594.
[Full Text]


Home page
CirculationHome page
M. Okabe, K. Fukuda, K. Arakawa, and M. Kikuchi
Chronic Variant of Myocarditis Associated With Hepatitis C Virus Infection
Circulation, July 1, 1997; 96(1): 22 - 24.
[Abstract] [Full Text]


Home page
CirculationHome page
S. Ishiyama, M. Hiroe, T. Nishikawa, S. Abe, T. Shimojo, H. Ito, S. Ozasa, K. Yamakawa, M. Matsuzaki, M. U. Mohammed, et al.
Nitric Oxide Contributes to the Progression of Myocardial Damage in Experimental Autoimmune Myocarditis in Rats
Circulation, January 21, 1997; 95(2): 489 - 496.
[Abstract] [Full Text]


Home page
INT J SURG PATHOLHome page
E. Cabrera-Pozuelo, J. F. Val-Bernal, J. M. Torre-Hernandez, R. Gomez-Izquierdo, and J. A. Gutierrez-Sanchez
Idiopathic Giant Cell Myocarditis Diagnosed in the Native Explanted Heart: Case Report and Literature Review
International Journal of Surgical Pathology, January 1, 1996; 4(3): 179 - 182.
[Abstract] [PDF]


Home page
ANGIOLOGYHome page
G. M. Folger JR, E. A. Eltohami, and H. A. Hajar
Acute Myocardial-Infarction-Like Findings with Myocarditis in Infancy: A Case Report
Angiology, August 1, 1994; 45(8): 737 - 741.
[Abstract] [PDF]


Home page
NEJMHome page
L. G. Lange and G. F. Schreiner
Immune Mechanisms of Cardiac Disease
N. Engl. J. Med., April 21, 1994; 330(16): 1129 - 1135.
[Full Text]




HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 1991 by the American College of Cardiology Foundation.