|
|
||||||||||
|
J Am Coll Cardiol, 1991; 18:1243-1250 © 1991 by the American College of Cardiology Foundation |
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
The purpose of this study was to determine whether age-related alterations in Doppler diastolic filling indexes occur independent of cardiovascular disease and confounding physiologic variables. Ten old (62 to 73 years) and 10 young (21 to 32 years) healthy male volunteers were rigorously screened for cardiovascular disease and underwent comprehensive Doppler echocardiography, radionuclide ventriculography and invasive measurements of right heart and left atrial pressures. There were no differences between the two groups in the physiologic variables of left ventricular mass, volumes, ejection fraction, end-systolic wall stress, left atrial size, heart rate and right atrial, pulmonary artery, pulmonary capillary wedge and systemic arterial pressures. However, there were marked differences in Doppler left ventricular filling indexes. Compared with the young group, the old group had reduced peak early diastolic flow velocity (56 +/- 13 vs. 82 +/- 12 cm/s, p = 0.0002) and increased atrial diastolic flow velocity (59 +/- 14 vs. 43 +/- 10 cm/s, p = 0.009) and had a peak atrial/early flow velocity (A/E) ratio twice that of the young group (1.09 +/- 0.29 vs. 0.54 +/- 0.15, p less than 0.0001). Similar results were obtained for the time-velocity integrals of the peaks. Subjects in the old group also had a markedly reduced peak filling rate (274 +/- 62 vs. 448 +/- 152 ml/s, p = 0.004). In univariate and multivariate regression analyses, peak early and atrial flow velocities were not related to any of the physiologic variables measured once age was accounted for, although peak filling rate, a volumetric measure flow, was related to body surface area as well as age.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
![]() |
F. Bukachi, A. Waldenstrom, S. Morner, P. Lindqvist, M.Y. Henein, and E. Kazzam Age dependency in the timing of mitral annular motion in relation to ventricular filling in healthy subjects: Umea General Population Heart Study Eur J Echocardiogr, July 1, 2008; 9(4): 522 - 529. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Lumens, T. Delhaas, T. Arts, B. R. Cowan, and A. A. Young Impaired subendocardial contractile myofiber function in asymptomatic aged humans, as detected using MRI Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1573 - H1579. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Iwashima, T. Horio, K. Kamide, H. Rakugi, T. Ogihara, and Y. Kawano Uric Acid, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension Hypertension, February 1, 2006; 47(2): 195 - 202. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. E. Meyer, S. J. Kovacs, A. A. Ehsani, S. Klein, J. O. Holloszy, and L. Fontana Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans J. Am. Coll. Cardiol., January 17, 2006; 47(2): 398 - 402. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Prasad, K. Okazaki, A. A. Zadeh, E. Dijk, Q. Fu, J. D. Thomas, and B. D. Levine Abnormalities of Doppler Measures of Diastolic Function in the Healthy Elderly Are Not Related to Alterations of Left Atrial Pressure Circulation, March 29, 2005; 111(12): 1499 - 1503. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Bukachi, A. Waldenstrom, S. Morner, P. Lindqvist, M.Y. Henein, and E. Kazzam Pulmonary venous flow reversal and its relationship to atrial mechanical function in normal subjects - Umea General Population Heart Study Eur J Echocardiogr, March 1, 2005; 6(2): 107 - 116. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. I. Karvounis, C. E. Papadopoulos, T. A. Zaglavara, I. G. Nouskas, K. D. Gemitzis, G. E. Parharidis, and G. E. Louridas Evidence of Left Ventricular Dysfunction in Asymptomatic Elderly Patients with Non-insulin-dependent Diabetes Mellitus Angiology, September 1, 2004; 55(5): 549 - 555. [Abstract] [PDF] |
||||
![]() |
M. R. Zile, C. F. Baicu, and W. H. Gaasch Diastolic Heart Failure -- Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle N. Engl. J. Med., May 6, 2004; 350(19): 1953 - 1959. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Skaluba and S. E. Litwin Mechanisms of Exercise Intolerance: Insights From Tissue Doppler Imaging Circulation, March 2, 2004; 109(8): 972 - 977. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. S. Hees, J. L. Fleg, S.-J. Dong, and E. P. Shapiro MRI and echocardiographic assessment of the diastolic dysfunction of normal aging: altered LV pressure decline or load? Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H782 - H788. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Baldi, K. McFarlane, H. C. Oxenham, G. A. Whalley, H. J. Walsh, and R. N. Doughty Left ventricular diastolic filling and systolic function of young and older trained and untrained men J Appl Physiol, December 1, 2003; 95(6): 2570 - 2575. [Abstract] [Full Text] |
||||
![]() |
T. Kato, A. Noda, H. Izawa, T. Nishizawa, F. Somura, A. Yamada, K. Nagata, M. Iwase, A. Nakao, and M. Yokota Myocardial velocity gradient as a noninvasively determined index of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy J. Am. Coll. Cardiol., July 16, 2003; 42(2): 278 - 285. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. G. Fonseca, H. C. Oxenham, B. R. Cowan, C. J. Occleshaw, and A. A. Young Aging alters patterns of regional nonuniformity in LV strain relaxation: a 3-D MR tissue tagging study Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H621 - H630. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. W. Kitzman, W. C. Little, P. H. Brubaker, R. T. Anderson, W. G. Hundley, C. T. Marburger, B. Brosnihan, T. M. Morgan, and K. P. Stewart Pathophysiological Characterization of Isolated Diastolic Heart Failure in Comparison to Systolic Heart Failure JAMA, November 6, 2002; 288(17): 2144 - 2150. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. S. Gottdiener, R. L. McClelland, R. Marshall, L. Shemanski, C. D. Furberg, D. W. Kitzman, M. Cushman, J. Polak, J. M. Gardin, B. J. Gersh, et al. Outcome of Congestive Heart Failure in Elderly Persons: Influence of Left Ventricular Systolic Function: The Cardiovascular Health Study Ann Intern Med, October 15, 2002; 137(8): 631 - 639. [Abstract] [Full Text] [PDF] |
||||
![]() |
K T Spencer, V Mor-Avi, J Gorcsan III, A N DeMaria, T R Kimball, M J Monaghan, J E Perez, L Weinert, J Bednarz, K Edelman, et al. Effects of aging on left atrial reservoir, conduit, and booster pump function: a multi-institution acoustic quantification study Heart, March 1, 2001; 85(3): 272 - 277. [Abstract] [Full Text] |
||||
![]() |
L. J. M. Kroft, P. Simons, J. M. van Laar, and A. de Roos Patients with Pulmonary Fibrosis: Cardiac Function Assessed with MR Imaging Radiology, August 1, 2000; 216(2): 464 - 471. [Abstract] [Full Text] |
||||
![]() |
J. G. Warner Jr., D. C. Metzger, D. W. Kitzman, D. J. Wesley, and W. C. Little Losartan improves exercise tolerance in patients with diastolic dysfunction and a hypertensive response to exercise J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1567 - 1572. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Bueno, R. Lopez-Palop, J. Bermejo, J. L. Lopez-Sendon, and J. L. Delcan In-Hospital Outcome of Elderly Patients With Acute Inferior Myocardial Infarction and Right Ventricular Involvement Circulation, July 15, 1997; 96(2): 436 - 441. [Abstract] [Full Text] |
||||
![]() |
T. Yamakado, E. Takagi, S. Okubo, K. Imanaka-Yoshida, T. Tarumi, M. Nakamura, and T. Nakano Effects of Aging on Left Ventricular Relaxation in Humans: Analysis of Left Ventricular Isovolumic Pressure Decay Circulation, February 18, 1997; 95(4): 917 - 923. [Abstract] [Full Text] |
||||
![]() |
J. N. Bella, V. Palmieri, M. J. Roman, J. E. Liu, T. K. Welty, E. T. Lee, R. R. Fabsitz, B. V. Howard, and R. B. Devereux Mitral Ratio of Peak Early to Late Diastolic Filling Velocity as a Predictor of Mortality in Middle-Aged and Elderly Adults: The Strong Heart Study Circulation, April 23, 2002; 105(16): 1928 - 1933. [Abstract] [Full Text] [PDF] |
||||
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |