Early and late effects of captopril treatment after large myocardial infarction in rats

Department of Internal Medicine, Veterans Affairs Medical Center, Portland, Oregon 97207.

The early (after 21 days) and late (after 4 months) effects of continuous treatment with captopril on left ventricular performance, weight and volumes were studied in rats with myocardial infarction. Early effects were examined in rats subjected to coronary ligation and randomized to either immediate treatment with captopril (2 g/liter drinking water) starting 2 h after surgery or no treatment. After 21 days, the treated group showed reductions in mean arterial, left ventricular systolic and left ventricular end-diastolic pressures compared with untreated rats. Right and left ventricular weight and left ventricular volumes were decreased and the ejection fraction index was increased by captopril treatment. To study the late effects of captopril, a second group of rats was randomized to immediate captopril treatment (starting 2 h after surgery), delayed captopril treatment (starting 21 days after surgery) or no treatment. When studied after 4 months of treatment, rats started on captopril treatment 2 h after infarction showed no differences compared with rats started on treatment 21 days after infarction. Treatment with captopril for 4 months produced changes that were similar to those in rats treated for 21 days. Captopril treatment improved hemodynamic function after myocardial infarction in rats examined after either 21 days or 4 months of treatment. The extent of the benefit was similar in the two treatment periods. Initiation of captopril therapy immediately after infarction did not appear to produce a greater effect than treatment started at 21 days after infarction in rats studied after the drug had been administered for 4 months.

This article has been cited by other articles:

				M Yoshiyama, Y Nakamura, T Omura, Y Izumi, R Matsumoto, S Oda, K Takeuchi, S Kim, H Iwao, and J Yoshikawa Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice Heart, August 1, 2005; 91(8): 1080 - 1085. [Abstract] [Full Text] [PDF]

				Y. Z. Zhu, H. S. Lee, Y. Z. Zhu, and H. S. Lee Angiotensin-Converting Enzyme Inhibition After Myocardial Infarction Asian Cardiovasc Thorac Ann, March 1, 2000; 8(1): 85 - 90. [Abstract] [Full Text] [PDF]

				S. Hugel, M. Horn, M. de Groot, H. Remkes, C. Dienesch, K. Hu, G. Ertl, and S. Neubauer Effects of ACE inhibition and beta -receptor blockade on energy metabolism in rats postmyocardial infarction Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2167 - H2175. [Abstract] [Full Text] [PDF]

				K. Harada, T. Sugaya, K. Murakami, Y. Yazaki, and I. Komuro Angiotensin II Type 1A Receptor Knockout Mice Display Less Left Ventricular Remodeling and Improved Survival After Myocardial Infarction Circulation, November 16, 1999; 100(20): 2093 - 2099. [Abstract] [Full Text] [PDF]

				M. Yoshiyama, K. Takeuchi, T. Omura, S. Kim, H. Yamagishi, I. Toda, M. Teragaki, K. Akioka, H. Iwao, and J. Yoshikawa Effects of Candesartan and Cilazapril on Rats With Myocardial Infarction Assessed by Echocardiography Hypertension, April 1, 1999; 33(4): 961 - 968. [Abstract] [Full Text] [PDF]

				C. Marie, C. Mossiat, C. Gros, J.-C. Schwartz, J.-M. Lecomte, and J. Bralet Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction Cardiovasc Res, March 1, 1999; 41(3): 544 - 553. [Abstract] [Full Text] [PDF]

				K. Hu, P. Gaudron, H.-J. Anders, F. Weidemann, O. Turschner, M. Nahrendorf, and G. Ertl Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin Cardiovasc Res, August 1, 1998; 39(2): 401 - 412. [Abstract] [Full Text] [PDF]

				N. Shimizu, M. Yoshiyama, T. Omura, A. Hanatani, S. Kim, K. Takeuchi, H. Iwao, and J. Yoshikawa Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats Cardiovasc Res, April 1, 1998; 38(1): 116 - 124. [Abstract] [Full Text] [PDF]

				T. Shimada, M. Yoshiyama, K. Takeuchi, T. Omura, Y. Takemoto, S. Kim, H. Iwao, and J. Yoshikawa Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats Cardiovasc Res, March 1, 1998; 37(3): 618 - 626. [Abstract] [Full Text] [PDF]

				W. W. Brooks, O. H. L. Bing, C. H. Conrad, L. O'Neill, M. T. Crow, E. G. Lakatta, D. E. Dostal, K. M. Baker, and M. O. Boluyt Captopril Modifies Gene Expression in Hypertrophied and Failing Hearts of Aged Spontaneously Hypertensive Rats Hypertension, December 1, 1997; 30(6): 1362 - 1368. [Abstract] [Full Text]

				P. Mulder, B. Devaux, V. Richard, J.-P. Henry, M.-C. Wimart, E. Thibout, B. Mace, and C. Thuillez Early Versus Delayed Angiotensin-Converting Enzyme Inhibition in Experimental Chronic Heart Failure: Effects on Survival, Hemodynamics, and Cardiovascular Remodeling Circulation, March 4, 1997; 95(5): 1314 - 1319. [Abstract] [Full Text]

				J. Gurevitch, D. Pevni, I. Frolkis, M. Matsa, Y. Paz, R. Mohr, and V. Yakirevich Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart Ann. Thorac. Surg., March 1, 1997; 63(3): 627 - 633. [Abstract] [Full Text]

				A. A. Voors Dr., J. H. Kingma, and W. H. van Gilst Drug Differences between ACE Inhibitors in Experimental Settings and Clinical Practice European Journal of Cardiovascular Prevention & Rehabilitation, October 1, 1995; 2(5): 413 - 422. [Abstract] [PDF]

				M. D. Flather Dr., E. M. Lonn, and S. Yusuf Effects of ACE Inhibitors on Mortality When Started in the Early Phase of Myocardial Infarction: Evidence from the Larger Randomized Controlled Trials European Journal of Cardiovascular Prevention & Rehabilitation, October 1, 1995; 2(5): 423 - 428. [Abstract] [PDF]

				H. M. Stauss, Y.-C. Zhu, T. Redlich, D. Adamiak, A. Mott, K. C. Kregel, and T. Unger Angiotensin-Converting Enzyme Inhibition in Infarct-Induced Heart Failure in Rats: Bradykinin Versus Angiotensin II European Journal of Cardiovascular Prevention & Rehabilitation, October 1, 1994; 1(3): 255 - 262. [Abstract] [PDF]