Prognostic importance of the serum magnesium concentration in patients with congestive heart failure
SS Gottlieb,
L Baruch,
ML Kukin,
JL Bernstein,
ML Fisher,
and
M Packer
Division of Cardiology, Mount Sinai School of Medicine, New York, New York.
Magnesium abnormalities are common in patients with congestive heart failure but the clinical and prognostic significance of an abnormal serum magnesium concentration in this disorder has not been investigated. Therefore, the relation between serum magnesium concentration and the clinical characteristics and long-term outcome of 199 patients with chronic heart failure was evaluated. The serum magnesium concentration was less than 1.6 mEq/liter in 38 patients (19%), within the normal range in 134 patients (67%) and greater than 2.1 mEq/liter in 27 patients (14%). Patients with hypomagnesemia had more frequent ventricular premature complexes and episodes of ventricular tachycardia than did patients with a normal serum magnesium concentration (p less than 0.05). Even though the two groups were similar with respect to severity of heart failure and neurohormonal variables, patients with a low serum magnesium concentration had a significantly worse prognosis during long-term follow-up (45% versus 71% 1 year survival, p less than 0.05). Patients with hypermagnesemia had more severe symptoms, greater neurohormonal activation and worse renal function than did patients with a normal serum magnesium concentration but tended to have fewer ventricular arrhythmias. Hypermagnesemic patients had a worse prognosis than did those with a normal magnesium concentration (37% versus 71% 1 year survival, p less than 0.05). In conclusion, the measurement of serum magnesium concentration provides important clinical and prognostic information in patients with chronic heart failure.
This article has been cited by other articles:
|
|
|
|
 
V. Soukoulis, J. B. Dihu, M. Sole, S. D. Anker, J. Cleland, G. C. Fonarow, M. Metra, E. Pasini, T. Strzelczyk, H. Taegtmeyer, et al.
Micronutrient deficiencies an unmet need in heart failure.
J. Am. Coll. Cardiol.,
October 27, 2009;
54(18):
1660 - 1673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Struthers
The clinical implications of aldosterone escape in congestive heart failure
Eur J Heart Fail,
August 1, 2004;
6(5):
539 - 545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D Struthers
Aldosterone blockade in heart failure
Journal of Renin-Angiotensin-Aldosterone System,
March 1, 2004;
5(1_suppl):
S23 - S27.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. E. Macdonald and A. D. Struthers
What is the optimal serum potassium level in cardiovascular patients?
J. Am. Coll. Cardiol.,
January 21, 2004;
43(2):
155 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Cohen, D Almoznino-Sarafian, R Zaidenstein, I Alon, O Gorelik, M Shteinshnaider, S Chachashvily, Z Averbukh, A Golik, Z Chen-Levy, et al.
Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive heart failure: pathophysiological correlates and prognostic evaluation
Heart,
April 1, 2003;
89(4):
411 - 416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. K. A. Witte, A. L. Clark, and J. G. F. Cleland
Chronic heart failure and micronutrients
J. Am. Coll. Cardiol.,
June 1, 2001;
37(7):
1765 - 1774.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Murasato, Y. Harada, M. Ikeda, Y. Nakashima, and Y. Hayashida
Effect of Magnesium Deficiency on Autonomic Circulatory Regulation in Conscious Rats
Hypertension,
August 1, 1999;
34(2):
247 - 252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. K. Campbell and J. Nadler
Magnesium Deficiency and Diabetes
The Diabetes Educator,
January 1, 1992;
18(1):
17 - 19.
[PDF]
|
|
|
|
|
|
|
M. Salem, N. Kasinski, A. M. Andrei, T. Brussel, M. R. Gold, A. Conn, and B. Chernow
Hypomagnesemia Is a Frequent Finding in the Emergency Department in Patients With Chest Pain
Arch Intern Med,
November 1, 1991;
151(11):
2185 - 2190.
[Abstract]
[PDF]
|
|
|
|
