Endothelial, platelet and leukocyte interactions in ischemic heart disease: insights into potential mechanisms and their clinical relevance
JL Dinerman
and
JL Mehta
Department of Medicine, University of Florida College of Medicine, Gainesville.
Recent investigations of the complex interactions among vascular endothelium, platelets and leukocytes have relevance to the pathogenesis of atherosclerosis and ischemic heart disease. Perturbations in the hemodynamic equilibrium maintained by these cellular elements may lead to vasospasm, in vivo thrombosis and a reduction in blood flow. Recent advances in the understanding of these interactions in health and disease states are summarized. The effect of pharmacologic agents on these cell-cell interactions are discussed to provide the reader with a general understanding of the relevance of these interactions in cardiovascular disease.
This article has been cited by other articles:
|
|
|
|
 
K. L. Margolis, J. E. Manson, P. Greenland, R. J. Rodabough, P. F. Bray, M. Safford, R. H. Grimm Jr, B. V. Howard, A. R. Assaf, R. Prentice, et al.
Leukocyte Count as a Predictor of Cardiovascular Events and Mortality in Postmenopausal Women: The Women's Health Initiative Observational Study
Arch Intern Med,
March 14, 2005;
165(5):
500 - 508.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.J. Chapman
Are the effects of statins on HDL-cholesterol clinically relevant?
Eur. Heart J. Suppl.,
July 1, 2004;
6(suppl_C):
C58 - C63.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.S. Celermajer
Understanding the pathophysiology of the arterial wall: which method should we choose?
Eur. Heart J. Suppl.,
September 1, 2002;
4(suppl_F):
F24 - F28.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Suzuki, S. Kawai, T. Aizawa, K. Kato, S. Sunayama, R. Okada, and H. Yamaguchi
Histological evaluation of coronary plaque in patients with variant angina: relationship between vasospasm and neointimal hyperplasia in primary coronary lesions
J. Am. Coll. Cardiol.,
January 1, 1999;
33(1):
198 - 205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-L. Wang, H. Chang, C.-R. Hung, and Y.-Z. Tseng
Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction
Cardiovasc Res,
December 1, 1998;
40(3):
557 - 563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Merhi, P. Provost, R. Guidoin, and J.-G. Latour
Importance of Platelets in Neutrophil Adhesion and Vasoconstriction After Deep Carotid Arterial Injury by Angioplasty in Pigs
Arterioscler Thromb Vasc Biol,
June 1, 1997;
17(6):
1185 - 1191.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
I. Ott, F.-J. Neumann, M. Gawaz, M. Schmitt, and A. Schomig
Increased Neutrophil-Platelet Adhesion in Patients With Unstable Angina
Circulation,
September 15, 1996;
94(6):
1239 - 1246.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. M. Hoffmeister, M. Jur, H. P. Wendel, W. Heller, and L. Seipel
Alterations of Coagulation and Fibrinolytic and Kallikrein-Kinin Systems in the Acute and Postacute Phases in Patients With Unstable Angina Pectoris
Circulation,
May 15, 1995;
91(10):
2520 - 2527.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Lopez-Farre, C. Caramelo, A. Esteban, M. L. Alberola, I. Millas, M. Monton, and S. Casado
Effects of Aspirin on Platelet-Neutrophil Interactions : Role of Nitric Oxide and Endothelin-1
Circulation,
April 1, 1995;
91(7):
2080 - 2088.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Michiels, T. Arnould, and J. Remacle
Hypoxia-Induced Activation of Endothelial Cells as a Possible Cause of Venous Diseases: Hypothesis
Angiology,
August 1, 1993;
44(8):
639 - 646.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. C. Bone
Modulators of Coagulation: A Critical Appraisal of Their Role in Sepsis
Arch Intern Med,
July 1, 1992;
152(7):
1381 - 1389.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. C. Bone
The Pathogenesis of Sepsis
Ann Intern Med,
September 15, 1991;
115(6):
457 - 469.
[Abstract]
[PDF]
|
|
|
|
