Advertisement

Click here for more guidelines.

 
 




CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 1990; 15:15-20
© 1990 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sethi, G.
Right arrow Articles by Henderson, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sethi, G.
Right arrow Articles by Henderson, W.

Implications of preoperative administration of aspirin in patients undergoing coronary artery bypass grafting. Department of Veterans Affairs Cooperative Study on Antiplatelet Therapy

GK Sethi, JG Copeland, S Goldman, T Moritz, K Zadina, and WG Henderson

Division of Cardiothoracic Surgery, Department of Veterans Affairs Medical Center, Tucson, Arizona 85723.

The perioperative consequences of preoperative aspirin administration were assessed in a large prospective cooperative study of 772 patients undergoing coronary artery bypass grafting. The 772 patients were randomized to receive either aspirin (325 mg once a day), aspirin (325 mg three times a day), aspirin plus dipyridamole (325 and 75 mg together three times a day) (aspirin group), sulfinpyrazone (267 mg three times a day) or placebo (nonaspirin group). The therapy, except in the aspirin group, was started 48 h before the operation. In all aspirin subgroups, one 325 mg aspirin dose was given 12 h before surgery and maintained thereafter according to the assigned regimen. Patients in the aspirin group had significantly more postoperative bleeding and received more packed blood cells and blood products than did patients in the nonaspirin group. Although total operative duration and cardiopulmonary bypass duration were not different, the interval between completion of cardiopulmonary bypass and wound closure was significantly longer (p = 0.035) in the aspirin group. Thirty-one (6.6%) of 471 patients in the aspirin group and 5 (1.7%) of 301 patients in the nonaspirin group also required reoperation for control of postoperative bleeding (p = 0.002). The site of bleeding found at reoperation was not different between the two groups. There was no difference in operative mortality rates, incidence of other bleeding complications or occurrence of other post-operative complications between the two groups. Thus, antiplatelet regimens involving preoperative initiation of aspirin therapy, which has been shown to improve graft patency, increase the risk of abnormal postoperative bleeding and the need for reoperation.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
ChestHome page
J. D. Douketis, A. C. Spyropoulos, F. A. Spencer, M. Mayr, A. K. Jaffer, M. H. Eckman, A. S. Dunn, and R. Kunz
Perioperative Management of Antithrombotic Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Chest, February 1, 2012; 141(2_suppl): e326S - e350S.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
Writing Committee Members, L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, et al.
2011 ACCF/AHA guideline for coronary artery bypass graft surgery: Executive summary A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
J. Thorac. Cardiovasc. Surg., January 1, 2012; 143(1): 4 - 34.
[Full Text] [PDF]


Home page
Anesth. Analg.Home page
L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, A. M. Hutter Jr, et al.
Special Article: 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Anesth. Analg., January 1, 2012; 114(1): 11 - 45.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, A. M. Hutter Jr, et al.
2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons
J. Am. Coll. Cardiol., December 6, 2011; 58(24): 2584 - 2614.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, A. M. Hutter Jr, et al.
2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons
J. Am. Coll. Cardiol., December 6, 2011; 58(24): e123 - e210.
[Full Text] [PDF]


Home page
CirculationHome page
Writing Committee Members, L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, et al.
2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Circulation, December 6, 2011; 124(23): e652 - e735.
[Full Text] [PDF]


Home page
CirculationHome page
Writing Committee Members, L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, et al.
2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Circulation, December 6, 2011; 124(23): 2610 - 2642.
[Full Text] [PDF]


Home page
CirculationHome page
M. Jacob, N. Smedira, E. Blackstone, S. Williams, and L. Cho
Effect of Timing of Chronic Preoperative Aspirin Discontinuation on Morbidity and Mortality in Coronary Artery Bypass Surgery
Circulation, February 15, 2011; 123(6): 577 - 583.
[Abstract] [Full Text] [PDF]


Home page
Circ Cardiovasc Qual OutcomesHome page
R. H. Mehta, S. Sheng, S. M. O'Brien, F. L. Grover, J. S. Gammie, T. B. Ferguson, E. D. Peterson, and on behalf of the Society of Thoracic Surgeons Nati
Reoperation for Bleeding in Patients Undergoing Coronary Artery Bypass Surgery: Incidence, Risk Factors, Time Trends, and Outcomes
Circ Cardiovasc Qual Outcomes, November 1, 2009; 2(6): 583 - 590.
[Abstract] [Full Text] [PDF]


Home page
AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
J. Hopkins and M. Limacher
The Role of Aspirin in Cardiovascular Disease Prevention in Women
American Journal of Lifestyle Medicine, March 1, 2009; 3(2): 123 - 134.
[Abstract] [PDF]


Home page
Eur J Cardiothorac SurgHome page
G. Suwalski, P. Suwalski, K. J. Filipiak, M. Postula, F. Majstrak, and G. Opolski
The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day
Eur J Cardiothorac Surg, August 1, 2008; 34(2): 365 - 369.
[Abstract] [Full Text] [PDF]


Home page
Eur J Cardiothorac SurgHome page
J. Dunning, M. Versteegh, A. Fabbri, A. Pavie, P. Kolh, U. Lockowandt, S. A. M. Nashef, and on behalf of the EACTS Audit and Guidelines Commit
Guideline on antiplatelet and anticoagulation management in cardiac surgery
Eur J Cardiothorac Surg, July 1, 2008; 34(1): 73 - 92.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
S. Schulman, R. J. Beyth, C. Kearon, and M. N. Levine
Hemorrhagic Complications of Anticoagulant and Thrombolytic Treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Chest, June 1, 2008; 133(6_suppl): 257S - 298S.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
J. D. Douketis, P. B. Berger, A. S. Dunn, A. K. Jaffer, A. C. Spyropoulos, R. C. Becker, and J. Ansell
The Perioperative Management of Antithrombotic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Chest, June 1, 2008; 133(6_suppl): 299S - 339S.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
M. Sobel and R. Verhaeghe
Antithrombotic Therapy for Peripheral Artery Occlusive Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Chest, June 1, 2008; 133(6_suppl): 815S - 843S.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
J. C.J. Sun, R. Whitlock, J. Cheng, J. W. Eikelboom, L. Thabane, M. A. Crowther, and K. H.T. Teoh
The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies
Eur. Heart J., April 2, 2008; 29(8): 1057 - 1071.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
The Society of Thoracic Surgeons Blood Conservatio, V. A. Ferraris, S. P. Ferraris, S. P. Saha, E. A. Hessel II, C. K. Haan, B. D. Royston, C. R. Bridges, R. S.D. Higgins, G. Despotis, et al.
Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline
Ann. Thorac. Surg., May 1, 2007; 83(5_Supplement): S27 - S86.
[Abstract] [Full Text] [PDF]


Home page
haematolHome page
G. Renda, R. Di Pillo, A. D'Alleva, A. Sciartilli, M. Zimarino, E. De Candia, R. Landolfi, G. Di Giammarco, A. Calafiore, and R. De Caterina
Surgical bleeding after pre-operative unfractionated heparin and low molecular weight heparin for coronary bypass surgery
Haematologica, March 1, 2007; 92(3): 366 - 373.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
K. A. Bybee, B. D. Powell, U. Valeti, A. G. Rosales, S. L. Kopecky, C. Mullany, and R. S. Wright
Preoperative Aspirin Therapy Is Associated With Improved Postoperative Outcomes in Patients Undergoing Coronary Artery Bypass Grafting
Circulation, August 30, 2005; 112(9_suppl): I-286 - I-292.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
J. C.J. Sun, M. A. Crowther, T. E. Warkentin, A. Lamy, and K. H.T. Teoh
Should Aspirin Be Discontinued Before Coronary Artery Bypass Surgery?
Circulation, August 16, 2005; 112(7): e85 - e90.
[Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
C. P. Cannon, S. R. Mehta, and S. F. Aranki
Balancing the Benefit and Risk of Oral Antiplatelet Agents in Coronary Artery Bypass Surgery
Ann. Thorac. Surg., August 1, 2005; 80(2): 768 - 779.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
A. E. Epstein, J. C. Alexander, D. D. Gutterman, W. Maisel, and J. M. Wharton
Anticoagulation: American College of Chest Physicians Guidelines for the Prevention and Management of Postoperative Atrial Fibrillation After Cardiac Surgery
Chest, August 1, 2005; 128(2_suppl): 24S - 27S.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
V. A. Ferraris, S. P. Ferraris, D. J. Moliterno, P. Camp, J. M. Walenga, H. L. Messmore, W. P. Jeske, F. H. Edwards, D. Royston, D. M. Shahian, et al.
The Society of Thoracic Surgeons Practice Guideline Series: Aspirin and Other Antiplatelet Agents During Operative Coronary Revascularization (Executive Summary)
Ann. Thorac. Surg., April 1, 2005; 79(4): 1454 - 1461.
[Full Text] [PDF]


Home page
SEMIN CARDIOTHORAC VASC ANESTHHome page
A. Shander, D. Moskowitz, and T. S. Rijhwani
The Safety and Efficacy of "Bloodless" Cardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2005; 9(1): 53 - 63.
[Abstract] [PDF]


Home page
CLIN APPL THROMB HEMOSTHome page
G. F. Pineo and R. D. Hull
Low-Molecular-Weight Heparin for the Treatment of Venous Thromboembolism in the Elderly
Clinical and Applied Thrombosis/Hemostasis, January 1, 2005; 11(1): 15 - 23.
[Abstract] [PDF]


Home page
ChestHome page
M. N. Levine, G. Raskob, R. J. Beyth, C. Kearon, and S. Schulman
Hemorrhagic Complications of Anticoagulant Treatment: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
Chest, September 1, 2004; 126(3_suppl): 287S - 310S.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
G. P. Clagett, M. Sobel, M. R. Jackson, G. Y. H. Lip, M. Tangelder, and R. Verhaeghe
Antithrombotic Therapy in Peripheral Arterial Occlusive Disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
Chest, September 1, 2004; 126(3_suppl): 609S - 626S.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
S. Karthik, A. D. Grayson, E. E. McCarron, D. M. Pullan, and M. J. Desmond
Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay
Ann. Thorac. Surg., August 1, 2004; 78(2): 527 - 534.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
K. Furukawa and H. Ohteki
Changes in platelet aggregation after suspension of aspirin therapy
J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1814 - 1815.
[Full Text] [PDF]


Home page
Eur J Cardiothorac SurgHome page
H. Karabulut, F. Toraman, S. Evrenkaya, O. Goksel, S. Tarcan, and C. Alhan
Clopidogrel does not increase bleeding and allogenic blood transfusion in coronary artery surgery
Eur J Cardiothorac Surg, March 1, 2004; 25(3): 419 - 423.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
D. M. Moskowitz, J. J. Klein, A. Shander, K. M. Cousineau, R. S. Goldweit, C. Bodian, S. I. Perelman, H. Kang, D. A. Fink, H. C. Rothman, et al.
Predictors of transfusion requirements for cardiac surgical procedures at a blood conservation center
Ann. Thorac. Surg., February 1, 2004; 77(2): 626 - 634.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
J. M. Foody, F. D. Ferdinand, D. Galusha, S. S. Rathore, F. A. Masoudi, E. P. Havranek, D. Nilasena, M. J. Radford, and H. M. Krumholz
Patterns of Secondary Prevention in Older Patients Undergoing Coronary Artery Bypass Grafting During Hospitalization for Acute Myocardial Infarction
Circulation, September 9, 2003; 108(2011): II-24 - II-28.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
A. K. Srinivasan, A. D. Grayson, D. M. Pullan, B. M. Fabri, and W. C. Dihmis
Effect of preoperative aspirin use in off-pump coronary artery bypass operations
Ann. Thorac. Surg., July 1, 2003; 76(1): 41 - 45.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
F. J.F. Herth, H.D. Becker, and A. Ernst
Aspirin Does Not Increase Bleeding Complications After Transbronchial Biopsy
Chest, October 1, 2002; 122(4): 1461 - 1464.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
R. H. Hongo, J. Ley, S. E. Dick, and R. R. Yee
The effect of clopidogrel incombination with aspirin whengiven before coronary artery bypass grafting
J. Am. Coll. Cardiol., July 17, 2002; 40(2): 231 - 237.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
J. M. Alvarez, L. R. Jackson, C. Chatwin, and J. J. Smolich
Low-dose postoperative aprotinin reduces mediastinal drainage and blood product use in patients undergoing primary coronary artery bypass grafting who are taking aspirin: A prospective, randomized, double-blind, placebo-controlled trial
J. Thorac. Cardiovasc. Surg., September 1, 2001; 122(3): 457 - 463.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
M. N. Levine, G. Raskob, S. Landefeld, and C. Kearon
Hemorrhagic Complications of Anticoagulant Treatment
Chest, January 1, 2001; 119(2009): 108S - 121S.
[Full Text] [PDF]


Home page
ChestHome page
M. R. Jackson and G. P. Clagett
Antithrombotic Therapy in Peripheral Arterial Occlusive Disease
Chest, January 1, 2001; 119(2009): 283S - 299S.
[Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
L. J. Dacey, J. J. Munoz, E. R. Johnson, B. J. Leavitt, C. T. Maloney, J. R. Morton, E. M. Olmstead, J. D. Birkmeyer, and G. T. O'Connor
Effect of preoperative aspirin use on mortality in coronary artery bypass grafting patients
Ann. Thorac. Surg., December 1, 2000; 70(6): 1986 - 1990.
[Abstract] [Full Text] [PDF]


Home page
PerfusionHome page
S. V Moran, G. Lema, J. Medel, M. J Irarrazaval, R. Zalaquett, B. Garayar, and R. Flaskamp
Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery
Perfusion, March 1, 2000; 15(2): 105 - 110.
[Abstract] [PDF]


Home page
Ann. Thorac. Surg.Home page
B. P. Bidstrup, B. J. Hunt, S. Sheikh, R. N. Parratt, J. M. Bidstrup, and R. N. Sapsford
Amelioration of the bleeding tendency of preoperative aspirin after aortocoronary bypass grafting
Ann. Thorac. Surg., February 1, 2000; 69(2): 541 - 547.
[Abstract] [Full Text] [PDF]


Home page
DTBHome page
Drugs in the peri-operative period: 4 - Cardiovascular drugs
DTB, December 1, 1999; 37(12): 89 - 92.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
K. A. Eagle, R. A. Guyton, R. Davidoff, G. A. Ewy, J. Fonger, T. J. Gardner, J. P. Gott, H. C. Herrmann, R. A. Marlow, W. C. Nugent, et al.
ACC/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology/ American Heart Association task force on Practice Guidelines (Committee to revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery)
J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1262 - 1347.
[Full Text] [PDF]


Home page
CirculationHome page
J. Hirsh and J. Hoak
Management of Deep Vein Thrombosis and Pulmonary Embolism : A Statement for Healthcare Professionals From the Council on Thrombosis (in Consultation With the Council on Cardiovascular Radiology), American Heart Association
Circulation, June 15, 1996; 93(12): 2212 - 2245.
[Full Text]


Home page
Arch DermatolHome page
C. C. Otley, J. L. Fewkes, W. Frank, and S. M. Olbricht
Complications of Cutaneous Surgery in Patients Who Are Taking Warfarin, Aspirin, or Nonsteroidal Anti-inflammatory Drugs
Arch Dermatol, February 1, 1996; 132(2): 161 - 166.
[Abstract] [PDF]


Home page
Ann. Thorac. Surg.Home page
V. A. Ferraris, S. P. Ferraris, F. C. Lough, and W. R. Berry
Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting
Ann. Thorac. Surg., April 1, 1995; 59(4): 1036 - 1037.
[Abstract] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
J. M. Murkin, J. Lux, N. A. Shannon, G. M. Guiraudon, A. H. Menkis, F. N. McKenzie, and R. J. Novick
Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations
J. Thorac. Cardiovasc. Surg., February 1, 1994; 107(2): 554 - 561.
[Abstract] [Full Text]


Home page
BMJHome page
M J Underwood and R S More
The aspirin papers
BMJ, January 8, 1994; 308(6921): 71 - 2.
[Full Text]


Home page
Journal of Pharmacy PracticeHome page
B. L. Erstad and L. A. Neumayer
Massive Gastrointestinal Bleeding Associated With Ketorolac Administration
Journal of Pharmacy Practice, January 1, 1992; 5(3): xi - xii.
[PDF]


Home page
Ann. Thorac. Surg.Home page
G. K. Sethi, J. G. Copeland, T. Moritz, W. Henderson, K. Zadina, and S. Goldman
Comparison of postoperative comlications between saphenous vein and IMA grafts to left anterior descending coronary artery
Ann. Thorac. Surg., May 1, 1991; 51(5): 733 - 738.
[Abstract] [PDF]


Home page
Arch Intern MedHome page
G. Bashein, M. L. Nessly, A. L. Rice, R. B. Counts, and G. A. Misbach
Preoperative Aspirin Therapy and Reoperation for Bleeding After Coronary Artery Bypass Surgery
Arch Intern Med, January 1, 1991; 151(1): 89 - 93.
[Abstract] [PDF]


Home page
Ann. Thorac. Surg.Home page
W. J. scott, R. Kessler, and J. A. wernly
Blood conservation in cardiac surgery
Ann. Thorac. Surg., November 1, 1990; 50(5): 843 - 851.
[Abstract] [PDF]


Home page
JWatch GeneralHome page
THE DOWNSIDE OF ASPIRIN BEFORE CORONARY BYPASS SURGERY
Journal Watch (General), January 19, 1990; 1990(119): 6 - 6.
[Full Text]


Home page
PERSPECT VASC SURG ENDOVASC THERHome page
G. P. Clagett
Antithrombotic Drugs and Vascular Surgery
Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1990; 3(2): 79 - 102.
[PDF]



 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement