|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 1989; 14:660-665 © 1989 by the American College of Cardiology Foundation |
Department of Medicine, University of Rochester, New York.
Sonicated albumin has been proposed as a near ideal echocardiographic contrast agent with little myocardial toxicity or hemodynamic effect. Its use has not yet been reported in humans, partly because of difficulties in preparation. With use of the newly modified sonication method, 10 ml of 5% albumin was sonicated for 75 s with a 5.0 ml slow infusion of air. This resulted in microbubbles with a mean diameter (+/- SD) of 5 +/- microns). Fourteen patients undergoing routine coronary angiography were studied. One patient had normal coronary arteries; the other 13 had significant coronary artery disease. In a subgroup of nine patients, sonicated albumin and sonicated diatrizoate meglumine sodium (microbubble diameter 9 +/- 3 microns) were injected several minutes apart, using the same technique. Videodensity-time curves were obtained from a region of interest in the myocardium. Corrected peak contrast intensity (baseline contrast intensity subtracted from peak contrast intensity, gray scale U/pixel) for sonicated albumin and for sonicated diatrizoate meglumine sodium was 51 +/- 26 and 52 +/- 19, respectively (p = 0.89). Washout half-time (T1/2) for the two agents was 5.5 +/- 4.5 and 16.0 +/- 12.2 s, respectively (p = 0.01). One patient with unstable angina experienced transient chest pain after repeated albumin injections. No electrocardiographic changes, blood pressure changes or wall motion abnormalities were observed. Administered by intracoronary injection, sonicated 5% albumin is a safe and effective echocardiographic contrast agent for myocardial perfusion imaging, yielding excellent myocardial contrast with physiologic washout time.
This article has been cited by other articles:
|
|
 |
|
  V. Mor-Avi, E. G. Caiani, K. A. Collins, C. E. Korcarz, J. E. Bednarz, and R. M. Lang Combined Assessment of Myocardial Perfusion and Regional Left Ventricular Function by Analysis of Contrast-Enhanced Power Modulation Images Circulation, July 17, 2001; 104(3): 352 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Borger, K. S. Wei, R. D. Weisel, J. S. Ikonomidis, V. Rao, G. Cohen, T. Shirai, A. S. Omran, S. C. Siu, and H. Rakowski Myocardial perfusion during warm antegrade and retrograde cardioplegia: a contrast echo study Ann. Thorac. Surg., September 1, 1999; 68(3): 955 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sakuma, Y. Hayashi, K. Sumii, M. Imazu, and M. Yamakido Prediction of short- and intermediate-term prognoses of patients with acute myocardial infarction using myocardial contrast echocardiography one day after recanalization J. Am. Coll. Cardiol., October 1, 1998; 32(4): 890 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ito, K. Iwakura, H. Oh, T. Masuyama, M. Hori, Y. Higashino, K. Fujii, and T. Minamino Temporal Changes in Myocardial Perfusion Patterns in Patients With Reperfused Anterior Wall Myocardial Infarction : Their Relation to Myocardial Viability Circulation, February 1, 1995; 91(3): 656 - 662. [Abstract] [Full Text]
|
|
|
|
|
|
C. Teupe, S. Richter, B. Fisslthaler, V. Randriamboavonjy, C. Ihling, I. Fleming, R. Busse, A. M. Zeiher, and S. Dimmeler Vascular Gene Transfer of Phosphomimetic Endothelial Nitric Oxide Synthase (S1177D) Using Ultrasound-Enhanced Destruction of Plasmid-Loaded Microbubbles Improves Vasoreactivity Circulation, March 5, 2002; 105(9): 1104 - 1109. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
