Sources of variability for Doppler color flow mapping of regurgitant jets in an animal model of mitral regurgitation

Division of Cardiology, Veterans Administration Medical Center, San Diego, California.

To determine whether Doppler color flow mapping could be used to quantify changing levels of regurgitant flow and define the technical variables that influence the size of color flow images of regurgitant jets, nine stable hemodynamic states of mitral insufficiency were studied in four open chest sheep with regurgitant orifices of known size. The magnitude of mitral regurgitation was altered by phenylephrine infusion. Several technical variables, including the type of color flow instrument (Irex Aloka 880 versus Toshiba SSH65A), transducer frequency, pulse repetition frequency and gain level, were studied. Significant increases in the color flow area, but not in color jet width measurements, were seen after phenylephrine infusion for each regurgitant orifice. For matched levels of mitral regurgitation, an increase in gain resulted in a 125% increase in color flow area. An increase in the pulse repetition and transducer frequencies resulted in a 36% reduction and a 28% increase in color flow area, respectively. Jet area for matched regurgitant volumes was larger on the Toshiba compared with the Aloka instrument (5.2 +/- 3.1 versus 3.2 +/- 1.2 cm2, p less than 0.05). Color flow imaging of mitral regurgitant jets is dependent on various technical factors and the magnitude of regurgitation. Once these are standardized for a given patient, the measurement of color flow jet area may provide a means of making serial estimates of the severity of mitral insufficiency.

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