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J Am Coll Cardiol, 1989; 13:57-62
© 1989 by the American College of Cardiology Foundation
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The St. Jude valve prosthesis: analysis of the clinical results in 815 implants and the need for systemic anticoagulation

ML Myers, GM Lawrie, ES Crawford, JF Howell, GC Morris Jr, DH Glaeser, and ME DeBakey

Cora and Webb Mading Department of Surgery, Baylor College of Medicine, Houston, Texas 77030.

Between July 1979 and December 1984, 785 patients received 815 St. Jude Medical valve prostheses. Valve-related mortality in the follow-up period was due to thromboembolism in seven cases, anticoagulant-related hemorrhage in three and perivalvular leak in two. Freedom from valve-related death or reoperation at 3 years was 96.4% for aortic valve replacement and 98.3% for mitral valve replacement. The overall rate of thromboembolism was 2.6%/patient-year with warfarin, 9.2%/patient-year with antiplatelet medication and 15.6%/patient-year in patients with no anticoagulant therapy. One episode of thrombotic obstruction of a mitral valve, in a patient receiving no anticoagulant therapy, resulted in an occurrence rate of such obstruction of 0.22%/patient-year. Valve replacement with the St. Jude valve produced excellent clinical results, but long-term anticoagulation with warfarin was required to minimize thromboembolic complications. The use of antiplatelet agents alone provided inadequate protection.


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