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J Am Coll Cardiol, 1989; 13:145-152 © 1989 by the American College of Cardiology Foundation |
Department of Cardiology, Sequoia Hospital, Redwood City, California.
Sixty-five patients with symptomatic, drug-refractory, sustained ventricular tachycardia or fibrillation were treated with oral sotalol (80 to 480 mg twice daily). Sotalol was withdrawn in 11 patients because of continued inducibility of ventricular tachycardia at the time of follow-up electrophysiologic study. Therefore, the clinical effectiveness of sotalol could be evaluated in 54 patients followed up for 11.5 +/- 6 months (range 0.2 to 25). The actuarial incidence of successful sotalol therapy was 54 +/- 13% at 6 months and 47 +/- 13% at 12 months. In 39 patients who underwent electrophysiologic testing while receiving oral sotalol, the drug prevented the reinduction of ventricular tachycardia/fibrillation in 8 (20%). During follow-up study, arrhythmia recurred in 1 (17%) of 6 patients whose ventricular tachycardia was noninducible with oral sotalol and in 8 (44%) of 18 with inducible tachycardia but who were continued on oral sotalol therapy. Adverse effects were noted in 28 patients (42%), requiring drug withdrawal in 13 (22%) and dose reduction after hospital discharge in 10 (15%). Exacerbation of ventricular arrhythmia occurred in six patients (9%), one of whom had associated hypokalemia. Sotalol is frequently useful in the control of intractable, life-threatening ventricular arrhythmias, and its efficacy appears to be predicted by programmed stimulation. However, there is a high rate of limiting side effects, which precludes its use in a large number of patients, and a substantial risk of arrhythmia exacerbation.
This article has been cited by other articles:
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  C. Mewis, V. Kuhlkamp, J. Mermi, R. F. Bosch, and L. Seipel Long-term reproducibility of electrophysiologically guided therapy with sotalol in patients with ventricular tachyarrhythmias J. Am. Coll. Cardiol., June 1, 1999; 33(7): 1989 - 1995. [Abstract] [Full Text] [PDF]
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 P. Kovoor, V. Eipper, K. Byth, M.J. Cooper, J.B. Uther, and D.L. Ross Comparison of sotalol with amiodarone for long-term treatment of spontaneous sustained ventricular tachyarrhythmia based on coronary artery disease Eur. Heart J., March 1, 1999; 20(5): 364 - 374. [Abstract] [PDF]
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V. Kuhlkamp, C. Mewis, J. Mermi, R. F. Bosch, and L. Seipel Suppression of sustained ventricular tachyarrhythmias: a comparison of d,l-sotalol with no antiarrhythmic drug treatment J. Am. Coll. Cardiol., January 1, 1999; 33(1): 46 - 52. [Abstract] [Full Text] [PDF]
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 B. N. Singh Review : Sotalol: Current Status and Expanding Indications Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1999; 4(1): 49 - 65. [Abstract] [PDF]
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 D. Bocker, W. Haverkamp, M. Block, M. Borggrefe, D. Hammel, and G. Breithardt Comparison of d,l-Sotalol and Implantable Defibrillators for Treatment of Sustained Ventricular Tachycardia or Fibrillation in Patients With Coronary Artery Disease Circulation, July 15, 1996; 94(2): 151 - 157. [Abstract] [Full Text]
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K. Nademanee, H. E. Noll, and G. K. Feld Effects of Sotalol on His-Purkinje Conduction and Refractoriness in Humans Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1996; 1(1): 9 - 16. [Abstract] [PDF]
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C. Holubarsch, R. Schneider, B. Pieske, T. Ruf, G. Hasenfuss, G. Fraedrich, H. Posival, and H. Just Positive and Negative Inotropic Effects of DL-Sotalol and D-Sotalol in Failing and Nonfailing Human Myocardium Under Physiological Experimental Conditions Circulation, November 15, 1995; 92(10): 2904 - 2910. [Abstract] [Full Text]
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 S. H. Hohnloser and R. L. Woosley Sotalol N. Engl. J. Med., July 7, 1994; 331(1): 31 - 38. [Full Text]
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