Iodine-123 meta-iodobenzylguanidine scintigraphy: a noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy
J Schofer,
R Spielmann,
A Schuchert,
K Weber,
and
M Schluter
Department of Cardiology, University Hospital Eppendorf, Hamburg, West Germany.
Iodine-123 (I-123) meta-iodobenzylguanidine (MIBG) imaging was performed in 31 patients. Three patients were without cardiac disease and 28 had idiopathic dilated cardiomyopathy with various degrees of left ventricular dysfunction. The qualitatively assessed myocardial I-123 MIBG scintigrams and the myocardial versus mediastinal I-123 MIBG uptake ratio were related to I-123 MIBG activity and norepinephrine concentration determined from endomyocardial biopsy samples taken from the right side of the interventricular septum. Scintigrams and the MIBG uptake ratio were also related to plasma catecholamine concentrations, left ventricular ejection fraction and New York Heart Association functional class. Patients with distinct myocardial I-123 MIBG uptake (score 1) had a normal ejection fraction (58 +/- 16%). Patients with diffusely reduced uptake or scintigraphic defects (score 2) had a significantly lower ejection fraction (38 +/- 9%, p less than 0.05), whereas patients with shadowy or no visible myocardial uptake (score 3) had the lowest ejection fraction (23 +/- 6%, p less than 0.002 versus patients with score 2). The scintigraphically determined I-123 MIBG activity in the septal region correlated significantly with I-123 MIBG activity from the endomyocardial biopsy samples (r = 0.78, p less than 0.001, n = 9). The myocardial versus mediastinal I-123 MIBG activity ratio was significantly related to myocardial norepinephrine concentration (r = 0.63, n = 28) and to left ventricular ejection fraction (r = 0.74, n = 31). These data suggest that myocardial I-123 MIBG scintigraphy is a useful noninvasive method for the assessment of myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy.
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29(12):
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|
|
|
|
|
|
|
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June 1, 2008;
49(6):
907 - 914.
[Abstract]
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|
|
|
|
|
|
|
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December 1, 2007;
48(12):
1993 - 2000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Tsukamoto, K. Morita, M. Naya, M. Inubushi, C. Katoh, K. Nishijima, Y. Kuge, H. Okamoto, H. Tsutsui, and N. Tamaki
Decreased Myocardial {beta}-Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy
J. Nucl. Med.,
November 1, 2007;
48(11):
1777 - 1782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Sumino, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Long-Term Nicorandil Therapy Improves Cardiac Sympathetic Nerve Activity After Reperfusion Therapy in Patients with First Acute Myocardial Infarction
J. Nucl. Med.,
October 1, 2007;
48(10):
1676 - 1682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kioka, T. Yamada, T. Mine, T. Morita, Y. Tsukamoto, S. Tamaki, M. Masuda, K. Okuda, M. Hori, and M. Fukunami
Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging
Heart,
October 1, 2007;
93(10):
1213 - 1218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Wu, F. M. Bengel, and S. S. Gambhir
Cardiovascular Molecular Imaging
Radiology,
August 1, 2007;
244(2):
337 - 355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, T. Hatori, H. Sumino, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol
Eur. Heart J.,
April 4, 2007;
(2007)
ehm048v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, T. Hatori, H. Sumino, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity and Left Ventricular Remodeling in Patients With First Anterior Acute Myocardial Infarction
J. Am. Coll. Cardiol.,
February 13, 2007;
49(6):
667 - 674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Munch, K. Rosport, A. Bultmann, C. Baumgartner, Z. Li, L. Laacke, and M. Ungerer
Cardiac Overexpression of the Norepinephrine Transporter Uptake-1 Results in Marked Improvement of Heart Failure
Circ. Res.,
October 28, 2005;
97(9):
928 - 936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Isobe, H. Izawa, M. Iwase, M. Nanasato, M. Nonokawa, A. Ando, S. Ohshima, K. Nagata, K. Kato, T. Nishizawa, et al.
Cardiac 123I-MIBG Reflects Left Ventricular Functional Reserve in Patients with Nonobstructive Hypertrophic Cardiomyopathy
J. Nucl. Med.,
June 1, 2005;
46(6):
909 - 916.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction
J. Am. Coll. Cardiol.,
March 1, 2005;
45(5):
661 - 667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, T. Ishikawa, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity in Patients with Decompensated Congestive Heart Failure
J. Nucl. Med.,
July 1, 2004;
45(7):
1108 - 1113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. J. Akashi, K. Nakazawa, M. Sakakibara, F. Miyake, H. Musha, and K. Sasaka
123I-MIBG Myocardial Scintigraphy in Patients with "Takotsubo" Cardiomyopathy
J. Nucl. Med.,
July 1, 2004;
45(7):
1121 - 1127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.-i. Kato, T. Nozawa, N. Igarashi, M. Nonomura, N. Fujii, A. Igawa, H. Asanoi, Y. Yamada, M. Inoue, and H. Inoue
Discrepant Recovery Course of Sympathetic Neuronal Function and {beta}-Adrenoceptors in Rat Hearts After Reperfusion Following Transient Ischemia
J. Nucl. Med.,
June 1, 2004;
45(6):
1074 - 1080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Toyama, H. Hoshizaki, R. Seki, N. Isobe, H. Adachi, S. Naito, S. Oshima, and K. Taniguchi
Efficacy of Carvedilol Treatment on Cardiac Function and Cardiac Sympathetic Nerve Activity in Patients with Dilated Cardiomyopathy: Comparison with Metoprolol Therapy
J. Nucl. Med.,
October 1, 2003;
44(10):
1604 - 1611.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Effect of spironolactone on cardiacsympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy
J. Am. Coll. Cardiol.,
February 19, 2003;
41(4):
574 - 581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yamada, T. Shimonagata, M. Fukunami, K. Kumagai, H. Ogita, A. Hirata, M. Asai, N. Makino, H. Kioka, H. Kusuoka, et al.
Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure: A prospective study
J. Am. Coll. Cardiol.,
January 15, 2003;
41(2):
231 - 238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi
Spironolactone Improves Cardiac Sympathetic Nerve Activity and Symptoms in Patients with Congestive Heart Failure
J. Nucl. Med.,
October 1, 2002;
43(10):
1279 - 1285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Hoshizaki, S. Oshima, K. Taniguchi, T. Suzuki, and M. Kurabayashi
Dobutamine Gated Blood Pool Scintigraphy Predicts the Improvement of Cardiac Sympathetic Nerve Activity, Cardiac Function, and Symptoms After Treatment in Patients With Dilated Cardiomyopathy*
Chest,
August 1, 2002;
122(2):
542 - 548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Merlet, L. Hittinger, J. L. Dubois-Rande, and A. Castaigne
Myocardial Adrenergic Dysinnervation in Dilated Cardiomyopathy: Cornerstone or Epiphenomenon?
J. Nucl. Med.,
April 1, 2002;
43(4):
536 - 539.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Ogita, T Shimonagata, M Fukunami, K Kumagai, T Yamada, Y Asano, A Hirata, M Asai, H Kusuoka, M Hori, et al.
Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: a prospective study
Heart,
December 1, 2001;
86(6):
656 - 660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Wakabayashi, T. Nakata, A. Hashimoto, S. Yuda, K. Tsuchihashi, M. I. Travin, and K. Shimamoto
Assessment of Underlying Etiology and Cardiac Sympathetic Innervation to Identify Patients at High Risk of Cardiac Death
J. Nucl. Med.,
December 1, 2001;
42(12):
1757 - 1767.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Zhao, N. Shuke, W. Yamamoto, A. Okizaki, J. Sato, Y. Ishikawa, T. Ohta, N. Hasebe, K. Kikuchi, and T. Aburano
Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT
J. Nucl. Med.,
July 1, 2001;
42(7):
1017 - 1024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. V. Jayachandran, H. J. Sih, W. Winkle, D. P. Zipes, G. D. Hutchins, and J. E. Olgin
Atrial Fibrillation Produced by Prolonged Rapid Atrial Pacing Is Associated With Heterogeneous Changes in Atrial Sympathetic Innervation
Circulation,
March 14, 2000;
101(10):
1185 - 1191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Orimo, E Ozawa, S Nakade, T Sugimoto, and H Mizusawa
123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
August 1, 1999;
67(2):
189 - 194.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Sakata, M. Shirotani, H. Yoshida, R. Nawada, K. Obayashi, K. Togi, and N. Miho
Effects of Amlodipine and Cilnidipine on Cardiac Sympathetic Nervous System and Neurohormonal Status in Essential Hypertension
Hypertension,
June 1, 1999;
33(6):
1447 - 1452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cohen-Solal, Y. Esanu, D. Logeart, F. Pessione, C. Dubois, G. Dreyfus, R. Gourgon, and P. Merlet
Cardiac metaiodobenzylguanidine uptake in patients with moderate chronic heart failure: relationship with peak oxygen uptake and prognosis
J. Am. Coll. Cardiol.,
March 1, 1999;
33(3):
759 - 766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F Hartmann, S Ziegler, S Nekolla, M Hadamitzky, M Seyfarth, G Richardt, and M Schwaiger
Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography
Heart,
March 1, 1999;
81(3):
262 - 270.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H Kakuchi, T Sasaki, Y Ishida, K Komamura, and K Miyatake
Clinical usefulness of 123I meta-iodobenzylguanidine imaging in predicting the effectiveness of beta blockers for patients with idiopathic dilated cardiomyopathy before and soon after treatment
Heart,
February 1, 1999;
81(2):
148 - 152.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Sakata, M. Shirotani, H. Yoshida, and C. Kurata
Comparison of effects of enalapril and nitrendipine on cardiac sympathetic nervous system in essential hypertension
J. Am. Coll. Cardiol.,
August 1, 1998;
32(2):
438 - 443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schafers, H. Lerch, T. Wichter, C. G. Rhodes, A. A. Lammertsma, M. Borggrefe, F. Hermansen, O. Schober, G.u. Breithardt, and P. G. Camici
Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia
J. Am. Coll. Cardiol.,
July 1, 1998;
32(1):
181 - 186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ungerer, F. Hartmann, M. Karoglan, A. Chlistalla, S. Ziegler, G. Richardt, M. Overbeck, H. Meisner, A. Schomig, and M. Schwaiger
Regional In Vivo and In Vitro Characterization of Autonomic Innervation in Cardiomyopathic Human Heart
Circulation,
January 20, 1998;
97(2):
174 - 180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Rundqvist, G. Eisenhofer, M. Elam, and P. Friberg
Attenuated Cardiac Sympathetic Responsiveness During Dynamic Exercise in Patients With Heart Failure
Circulation,
February 18, 1997;
95(4):
940 - 945.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. L. Zaret and F. J. Wackers
Nuclear Cardiology- Second of Two Parts
N. Engl. J. Med.,
September 16, 1993;
329(12):
855 - 863.
[Full Text]
|
|
|
|
