Left ventricular distensibility and passive elastic stiffness in atrial septal defect

Division of Cardiology, Albert B. Chandler Medical Center, University of Kentucky College of Medicine, Lexington 40536.

Diminished left ventricular distensibility has been postulated as a cause of left ventricular failure in atrial septal defect. To evaluate this hypothesis the indexes of left ventricular compliance and stiffness were estimated in 15 patients with atrial septal defect and the results compared with those in 10 normal subjects. Age, peak left ventricular systolic pressure, end-diastolic pressure, ejection fraction and cardiac index did not differ significantly between groups. Left ventricular end-diastolic volume for the atrial septal defect group was significantly less than that for the control group (mean +/- SD, 61 +/- 9 ml/m2 versus 73 +/- 13, p less than 0.05) in keeping with previous studies. The slope of the log pressure-volume relation was significantly greater in the group with atrial septal defect than in the normal group (0.056 +/- 0.010 versus 0.044 +/- 0.008, p less than 0.01), consistent with increased chamber stiffness. For a group of six patients with atrial septal defect and elevated left ventricular end-diastolic pressure, normalized compliance was significantly less than that in the control group (0.017 +/- 0.001 versus 0.036 +/- 0.007, p less than 0.02). The slope k of the elastic stiffness-stress relation for the total group with atrial septal defect was significantly greater than that of the normal group (21.0 +/- 2.3 versus 18.1 +/- 2.3, p less than 0.01). An index of muscle fiber stretch (dV/VdP x end-diastolic stress x 100) was significantly less in the atrial septal defect group than in the control group (74 +/- 24 versus 106 +/- 22, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				R. J. Sommer, Z. M. Hijazi, and J. F. Rhodes Jr Pathophysiology of Congenital Heart Disease in the Adult: Part I: Shunt Lesions Circulation, February 26, 2008; 117(8): 1090 - 1099. [Full Text] [PDF]

				M Weber, T Dill, A Deetjen, T Neumann, O Ekinci, J Hansel, A Elsaesser, V Mitrovic, and C Hamm Left ventricular adaptation after atrial septal defect closure assessed by increased concentrations of N-terminal pro-brain natriuretic peptide and cardiac magnetic resonance imaging in adult patients Heart, May 1, 2006; 92(5): 671 - 675. [Abstract] [Full Text] [PDF]

				M. Pawelec-Wojtalik, M. Wojtalik, W. Mrowczynski, R. Surmacz, and S. A. Quereshi Comparison of cardiac function in children after surgical and Amplatzer occluder closure of secundum atrial septal defects Eur. J. Cardiothorac. Surg., January 1, 2006; 29(1): 89 - 92. [Abstract] [Full Text] [PDF]

				Y.-Q. Zhou, Y. Zhu, J. Bishop, L. Davidson, R. M. Henkelman, B. G. Bruneau, and F. S. Foster Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H992 - H1001. [Abstract] [Full Text] [PDF]

				H. Otani, Y. Kagaya, Y. Yamane, M. Chida, K. Ito, S. Namiuchi, N. Shiba, Y. Koseki, M. Ninomiya, J. Ikeda, et al. Long-Term Right Ventricular Volume Overload Increases Myocardial Fluorodeoxyglucose Uptake in the Interventricular Septum in Patients With Atrial Septal Defect Circulation, April 11, 2000; 101(14): 1686 - 1692. [Abstract] [Full Text] [PDF]

				M. A. Gatzoulis, M. A. Freeman, S. C. Siu, G. D. Webb, and L. Harris Atrial Arrhythmia after Surgical Closure of Atrial Septal Defects in Adults N. Engl. J. Med., March 18, 1999; 340(11): 839 - 846. [Abstract] [Full Text] [PDF]

				A. Elkouby, F. Panes, P. Durasnel, F. Razafindrainibe, R. Gohard, P. Lallemant, P. Real, H. Sadler, C. Meyer, M. Demoulin, et al. Acute cardiac failure after repair of atrial septal defect and coronary bypass: Treatment by femorofemoral assistance and intraaortic balloon pumping J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1373 - 1374. [Full Text]