Angiographic progression of coronary artery disease and the development of myocardial infarction
JA Ambrose,
MA Tannenbaum,
D Alexopoulos,
CE Hjemdahl-Monsen,
J Leavy,
M Weiss,
S Borrico,
R Gorlin,
and
V Fuster
Department of Medicine, New York Cardiac Center, Mount Sinai Medical Center, New York 10029.
There are few data on angiographic coronary artery anatomy in patients whose coronary artery disease progresses to myocardial infarction. In this retrospective analysis, progression of coronary artery disease between two cardiac catheterization procedures is described in 38 patients: 23 patients (Group I) who had a myocardial infarction between the two studies and 15 patients (Group II) who presented with one or more new total occlusions at the second study without sustaining an intervening infarction. In Group I the median percent stenosis on the initial angiogram of the artery related to the infarct at restudy was significantly less than the median percent stenosis of lesions that subsequently were the site of a new total occlusion in Group II (48 versus 73.5%, p less than 0.05). In the infarct-related artery in Group I, only 5 (22%) of 23 lesions were initially greater than 70%, whereas in Group II, 11 (61%) of 18 lesions that progressed to total occlusion were initially greater than 70% (p less than 0.01). In Group I, patients who developed a Q wave infarction had less severe narrowing at initial angiography in the subsequent infarct-related artery (34%) than did patients who developed a non-Q wave infarction (80%) (p less than 0.05). Univariate and multivariate analysis of angiographic and clinical characteristics present at initial angiography in Group I revealed proximal lesion location as the only significant predictor of evolution of lesions greater than or equal to 50% to infarction. This retrospective study suggests that myocardial infarction frequently develops from previously nonsevere lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
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R. E. Murphy, A. R. Moody, P. S. Morgan, A. L. Martel, G.S. Delay, S. Allder, S. T. MacSweeney, W. G. Tennant, J. Gladman, J. Lowe, et al.
Prevalence of Complicated Carotid Atheroma as Detected by Magnetic Resonance Direct Thrombus Imaging in Patients With Suspected Carotid Artery Stenosis and Previous Acute Cerebral Ischemia
Circulation,
June 24, 2003;
107(24):
3053 - 3058.
[Abstract]
[Full Text]
[PDF]
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H. Tomoda and N. Aoki
Clinical Evaluation of Coronary Lesion Characteristics in Acute Myocardial Infarction
Angiology,
May 1, 2003;
54(3):
277 - 285.
[Abstract]
[PDF]
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V. S. Monroe, R. A. Kerensky, E. Rivera, K. M. Smith, and C. J. Pepine
Pharmacologic plaque passivation for the reduction of recurrent cardiac events in acute coronary syndromes
J. Am. Coll. Cardiol.,
February 19, 2003;
41(4_Suppl_S):
23S - 30S.
[Abstract]
[Full Text]
[PDF]
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L. K. Newby, B. U. Goldmann, and E. M. Ohman
Troponin: an important prognostic marker and risk-stratification tool in non-ST-segment elevation acute coronary syndromes
J. Am. Coll. Cardiol.,
February 19, 2003;
41(4_Suppl_S):
31S - 36S.
[Abstract]
[Full Text]
[PDF]
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M. S. Beattie, M. G. Shlipak, H. Liu, W. S. Browner, N. B. Schiller, and M. A. Whooley
C-Reactive Protein and Ischemia in Users and Nonusers of {beta}-Blockers and Statins: Data From the Heart and Soul Study
Circulation,
January 21, 2003;
107(2):
245 - 250.
[Abstract]
[Full Text]
[PDF]
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F. Bea, E. Blessing, B. Bennett, M. Levitz, E. P. Wallace, and M. E. Rosenfeld
Simvastatin Promotes Atherosclerotic Plaque Stability in ApoE-Deficient Mice Independently of Lipid Lowering
Arterioscler Thromb Vasc Biol,
November 1, 2002;
22(11):
1832 - 1837.
[Abstract]
[Full Text]
[PDF]
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V. Fuster, R. Corti, Z.A. Fayad, and J.J. Badimon
Understanding the pathophysiology of the arterial wall: which method should we choose? Magnetic resonance imaging
Eur. Heart J. Suppl.,
September 1, 2002;
4(suppl_F):
F41 - F46.
[Abstract]
[PDF]
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K. K. Koh
Effects of estrogen on the vascular wall: vasomotor function and inflammation
Cardiovasc Res,
September 1, 2002;
55(4):
714 - 726.
[Full Text]
[PDF]
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T. J. Ryan
The Coronary Angiogram and Its Seminal Contributions to Cardiovascular Medicine Over Five Decades
Circulation,
August 6, 2002;
106(6):
752 - 756.
[Full Text]
[PDF]
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R. P. Choudhury, V. Fuster, J. J. Badimon, E. A. Fisher, and Z. A. Fayad
MRI and Characterization of Atherosclerotic Plaque: Emerging Applications and Molecular Imaging
Arterioscler Thromb Vasc Biol,
July 1, 2002;
22(7):
1065 - 1074.
[Abstract]
[Full Text]
[PDF]
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P. R. Moreno, K. R. Purushothaman, V. Fuster, and W. N. O'Connor
Intimomedial Interface Damage and Adventitial Inflammation Is Increased Beneath Disrupted Atherosclerosis in the Aorta: Implications for Plaque Vulnerability
Circulation,
May 28, 2002;
105(21):
2504 - 2511.
[Abstract]
[Full Text]
[PDF]
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R. A. Kerensky, M. Wade, P. Deedwania, W. E. Boden, C. J. Pepine, and Veterans Affairs Non-Q-Wave Infarction Strategies
Revisiting the culprit lesion in non-Q-wave myocardial infarction: Results from the VANQWISH trial angiographic core laboratory
J. Am. Coll. Cardiol.,
May 1, 2002;
39(9):
1456 - 1463.
[Abstract]
[Full Text]
[PDF]
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G.F. Gensini and B. Dilaghi
The unstable plaque
Eur. Heart J. Suppl.,
March 1, 2002;
4(suppl_B):
B22 - B27.
[Abstract]
[PDF]
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K. Karnicki, E. Komorowicz, D. N. Fass, W. G. Owen, and R. D. McBane II
Influence of Anatomical Location on Arterial Thrombosis
Arterioscler Thromb Vasc Biol,
February 1, 2002;
22(2):
342 - 347.
[Abstract]
[Full Text]
[PDF]
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R. Wayhs, A. Zelinger, and P. Raggi
High coronary artery calcium scores pose an extremely elevated risk for hard events
J. Am. Coll. Cardiol.,
January 16, 2002;
39(2):
225 - 230.
[Abstract]
[Full Text]
[PDF]
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J. A. Beckman, J. Ganz, M. A. Creager, P. Ganz, and S. Kinlay
Relationship of Clinical Presentation and Calcification of Culprit Coronary Artery Stenoses
Arterioscler Thromb Vasc Biol,
October 1, 2001;
21(10):
1618 - 1622.
[Abstract]
[Full Text]
[PDF]
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S. Flacke, S. Fischer, M. J. Scott, R. J. Fuhrhop, J. S. Allen, M. McLean, P. Winter, G. A. Sicard, P. J. Gaffney, S. A. Wickline, et al.
Novel MRI Contrast Agent for Molecular Imaging of Fibrin: Implications for Detecting Vulnerable Plaques
Circulation,
September 11, 2001;
104(11):
1280 - 1285.
[Abstract]
[Full Text]
[PDF]
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E.G. Zouridakis, R. Schwartzman, X. Garcia-Moll, I.D. Cox, S. Fredericks, D.W. Holt, and J.C. Kaski
Increased plasma endothelin levels in angina patients with rapid coronary artery disease progression
Eur. Heart J.,
September 1, 2001;
22(17):
1578 - 1584.
[Abstract]
[PDF]
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L. Schwartz and M. G. Bourassa
Evaluation of Patients With Chest Pain and Normal Coronary Angiograms
Arch Intern Med,
August 13, 2001;
161(15):
1825 - 1833.
[Full Text]
[PDF]
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D. A. Zvara
Treatment of Perioperative Myocardial Ischemia
Seminars in Cardiothoracic and Vascular Anesthesia,
July 1, 2001;
5(2):
166 - 183.
[Abstract]
[PDF]
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G. J. W. Bech, B. De Bruyne, N. H.J. Pijls, E. D. de Muinck, J. C.A. Hoorntje, J. Escaned, P. R. Stella, E. Boersma, J. Bartunek, J. J. Koolen, et al.
Fractional Flow Reserve to Determine the Appropriateness of Angioplasty in Moderate Coronary Stenosis : A Randomized Trial
Circulation,
June 19, 2001;
103(24):
2928 - 2934.
[Abstract]
[Full Text]
[PDF]
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T. Sharir, G. Germano, X. Kang, H. C. Lewin, R. Miranda, I. Cohen, R. D. Agafitei, J. D. Friedman, and D. S. Berman
Prediction of Myocardial Infarction Versus Cardiac Death by Gated Myocardial Perfusion SPECT: Risk Stratification by the Amount of Stress-Induced Ischemia and the Poststress Ejection Fraction
J. Nucl. Med.,
June 1, 2001;
42(6):
831 - 837.
[Abstract]
[Full Text]
[PDF]
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F. Ledru, P. Ducimetiere, S. Battaglia, D. Courbon, F. Beverelli, L. Guize, J.-L.e. Guermonprez, and B. Diebold
New diagnostic criteria for diabetes and coronary artery disease: insights from an angiographic study
J. Am. Coll. Cardiol.,
May 1, 2001;
37(6):
1543 - 1550.
[Abstract]
[Full Text]
[PDF]
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S. S. Lin, M. S. Lauer, C. R. Asher, D. M. Cosgrove, E. Blackstone, J. D. Thomas, and M. J. Garcia
Prediction of coronary artery disease in patients undergoing operations for mitral valve degeneration
J. Thorac. Cardiovasc. Surg.,
May 1, 2001;
121(5):
894 - 901.
[Abstract]
[Full Text]
[PDF]
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M. Aikawa and P. Libby
Vascular inflammation and activation: new targets for lipid lowering
Eur. Heart J. Suppl.,
May 1, 2001;
3(suppl_B):
B3 - B11.
[Abstract]
[PDF]
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J. Candell-Riera, O. Pereztol-Valdés, C. Santana-Boado, M. Missorici, G. Oller-Martínez, S. Aguadé-Bruix, J. Castell-Conesa, M. Simó, M. J. Díez-Castro, and J. Soler-Soler
Relationship Between the Location of the Most Severe Myocardial Perfusion Defects, the Most Severe Coronary Artery Stenosis, and the Site of Subsequent Myocardial Infarction
J. Nucl. Med.,
April 1, 2001;
42(4):
558 - 563.
[Abstract]
[Full Text]
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G.e. Helft, S. G. Worthley, V. Fuster, A. G. Zaman, C. Schechter, J. I. Osende, O. J. Rodriguez, Z. A. Fayad, J. T. Fallon, and J. J. Badimon
Atherosclerotic aortic component quantification by noninvasive magnetic resonance imaging: an in vivo study in rabbits
J. Am. Coll. Cardiol.,
March 15, 2001;
37(4):
1149 - 1154.
[Abstract]
[Full Text]
[PDF]
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