Click on image to view larger version.

Figure 7 Electron Microscopy

(A) No loss of myofilaments is seen in regular chow fed saline-treated animal. (B) Minimal myofilament loss in iron-rich chow fed animal treated with saline. (C) Regular chow fed doxorubicin-treated animal showed infrequent areas of myofilament loss (arrow) without any sarcoplasmic swelling. (D) Larger areas of myofilament loss (arrow) seen in iron-rich chow fed animals treated with doxorubicin. Iron-rich chow fed animals treated with doxorubicin show frequent and large areas of myofilament loss (arrow) accompanied by swelling of sarcoplasmic reticulum, which are characteristic changes seen in doxorubicin cardiotoxicity. N = nucleus.