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Figure 2 Effects of Simvastatin, L-Arginine, and Their Combination on Endothelium-Dependent and -Independent Vasodilation in Subjects With High ADMA

Endothelium-dependent (A) and endothelium-independent vasodilation (B) in the brachial artery as assessed by high-resolution ultrasound before and after 3 weeks of treatment with simvastatin, L-arginine sustained release (SR), or their combination, in subjects with elevated asymmetric dimethylarginine (ADMA) concentration. *p < 0.05 versus baseline or between groups as indicated. Hatched bars = before treatment; black bars = after treatment. GTN = nitroglycerin; n.s. = not significant.