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Figure 2 Vascular Immunostaining for Markers of Apoptosis in Reversible PHT and Irreversible PHT

The antiapoptotic protein Bcl-2 is not expressed in reversible pulmonary hypertension (PHT), but by endothelial cells of severely damaged pulmonary arteries in irreversible PHT in all cases (A). Endothelial cells of both groups expressed markers of apoptosis caspase-3 (B) and p53 (C). The arrow indicates immunostaining in the endothelial layer.