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Figure 4 PDE5 Activity in Vascular and Renal Beds of Control and Heart Failure Animals

Bar graphs illustrating the percentage of total phoshodiesterase activity that is attributable to cyclic guanosine monophosphate-specific type 5 phosphodiesterase (PDE5) in vascular (A) and renal (B) tissue obtained from non-failing (normal) and failing (heart failure) dogs. *p < 0.05 versus values in normal dogs. cGMP = cyclic guanosine monophosphate; IMCD = inner medullary collecting ducts; IVC = inferior vena cava.