Click on image to view larger version.

Figure 1 Nicotine increases capillary density in the ischemic hind limb. Murine model of hind limb ischemia: nicotine stimulates angiogenesis as assessed by an increase in capillary density. Systemic treatment with nicotine resulted in a significantly higher angiogenic response as compared with local administration of nicotine into the ischemic hind limb (n = 7 each group). PBS = phosphate-buffered saline. *p < 0.01 versus control; **p < 0.05 versus local nicotine.