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Figure 5 Indexes of Collagen Homeostasis in Hoe 140-Treated Sham and ACF Rats

Collagen volume percent (A), matrix metalloproteinase (MMP)-13 (B), tissue inhibitor of matrix metalloproteinase (TIMP)-1 (C), and TIMP-4 (D) levels at 2 days in sham (SHM) and ACF rats with and without Hoe 140 treatment. Data are presented as mean ± SEM, n values given in Table 3. *p < 0.008 (= 0.05/6) versus SHM; p < 0.008 versus ACF. Collagen volume and MMP-13 were analyzed via variance component, whereas TIMP-1 and -4 were analyzed using a Kruskal-Wallis test. Abbreviations as in Figure 1.