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Figure 3 Mechanical restitution curve (MRC) curve-fitting analysis for (A) metoprolol, (B) sotalol, and (C) verapamil. The left-hand panel shows representative raw and fitted data obtained from one patient in each group, before (closed circles, solid curve) and 10 min after (open circles, dashed curve) drug administration. The right-hand panel shows mean data from the fitted MRC before (closed circles) and after (open circles) drug administration. Abbreviations as in Figure 1.