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Figure 1 Time course of torsades de pointes (TdP) in double-blind (DB) atrial fibrillation (AF) trials, all of which required azimilide loading (17 cases), and in the open-label (OL) trials, only for those patients who were on placebo during the DB phase (7 cases) (A). Time course of TdP in the 39 cases without loading by treatment indication (17 AF OL, 15 ICD, 7 post-myocardial infarction [MI]) (B). Time course of TdP in patients with versus without loading in the DB trials (17 loaded, 14 not loaded) (C).