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Figure 4 Effects of carvedilol versus metoprolol controlled release/extended release (CR/XL) on renal, hepatic, and skeletal muscle blood flows. Carvedilol increased renal, hepatic, and skeletal muscle flow to a greater extent than metoprolol CR/XL (*p < 0.05 compared with before treatment). The indicated p values represent the differences in the carvedilol responses and the metoprolol responses by analysis of variance. Open bars = before treatment; solid bars = after treatment.