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Figure 2 Northern blot analysis of transgenic and endogenous HIF-1 in infarct, peri-infarct, and remote left ventricular regions at 24 h and 4 weeks after LAD ligation and in sham-operated hearts. + = HIF-1(+) hearts; – = HIF-1(–) hearts. Steady-state levels of transgenic HIF-1 mRNA are not affected by hypoxic conditions, while steady-state levels of endogenous HIF-1 mRNA are increased in early infarct and peri-infarct regions.