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Figure 2 Restoration of circulating nitric oxide (NO) pool by flavanol-rich cocoa drink. Randomized double-blind crossover design, ingestion of 100 ml flavanol-rich cocoa drink (176 to 185 mg flavanols) increased (A) circulating NO pool (plasma RXNO) and (B) flow-mediated dilation after 2 h (n = 11 smokers). Ingestion of the matched control drink had no significant effect on both parameters (C, D). Filled circles = individual values; open circles = means ± SE. *p < 0.05.