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Figure 1 Example of a Low-Dose Patient
T2*-weighted imaging at the carotid bifurcation, before (1) and after (2) ultrasmall superparamagnetic iron oxide (USPIO) infusion at the 3 time points of (A) 0, (B) 6, and (C) 12 weeks. Plaque demonstrating USPIO uptake can clearly be seen in the right upper quadrant in all cases (yellow arrowheads). Pre-USPIO imaging remains very similar at all 3 time points. No USPIO uptake is seen in the pre-USPIO imaging at 6 or 12 weeks, indicating that the Sinerem has been cycled out of the plaque, an important aspect if repeated infusions are to be used for multiple time point imaging and assessing progression of USPIO-defined inflammation in response to a drug intervention.