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Figure 5 Effect of RSR13 on Exercise Capacity of MI Mice

(A) Chemical structure of RSR13. (B) Effect of RSR13 on running distance by normal mice. Thirty minutes after RSR13 or vehicle injection, the exercise test was started. Total distance run for each 30-min period are shown. C = vehicle-treated control group; R = RSR13-treated group. (C and D) Effect of RSR13 on exercise capacity of MI mice. Four weeks after LCA ligation, RSR13 or vehicle was injected into the mice (n = 4 each), and 30 min after the injection, the exercise test was started. Total rest time and distance run for each 30-min period are shown in C and D, respectively. Data show the means ± SEM. *p < 0.05 versus corresponding control subjects. Abbreviations as in Figure 2.