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Figure 1 Characterization of Transplanted BMCs

(A) Detection of Presbyterian β (β^Pres)-globin. Reversed-phase high-performance liquid chromatography profiles of hemolysate prepared from WT (top) or Presbyterian bone marrow cell (BMC)-transplanted (bottom) mice. The peaks of -globin, WT (β^WT-globin), and β^Pres-globin are indicated. (B) The O₂ dissociation curves of the red blood cells from WT and Presbyterian BMC-transplanted mice measured at pH 7.4 (open circles and triangles) or at pH 6.9 (closed circles and triangles). Circles and triangles indicate WT and Presbyterian BMC transplanted mice, respectively. BMT = bone marrow cell transplantation; Pres = Presbyterian; WT = wild type.