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Figure 4 Chronic Exposure to Ang II–Induced Cardiac Apoptosis

Mice (n 5) were given Ang II at 0.5 mg/kg body weight for 2 weeks, during which the hearts were collected at 1 and 2 weeks for terminal transferase dUTP nick end labeling assay (A), Western blotting of activated caspase-3 (B), and colocalization of activated caspase-3 with cardiomyocytes (-sarcomeric actin) with immunofluorescent staining (C). *p < 0.05 versus corresponding control. Abbreviations as in Figure 1.