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Figure 2 Exercise Decreases Markers of Cellular Aging in the Heart

Representative Western blot analysis and quantification of the effects of voluntary exercise for 21 days on the left ventricular expression of (A) the senescence marker protein p16, (B) the cell-cycle–checkpoint kinase 2 (Chk2), and (C) the proapoptotic transcription factor p53. *p < 0.05, **p < 0.01, n = 8 to 12 per group. Abbreviation as in Figure 1.