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Figure 2 Plasma VEGF and sTie2 Levels Distinguish Patients With CLI From Control Subjects or Patients With IC

Plasma concentrations of Ang2, VEGF, and sTie2 were measured and compared in control subjects (n = 23) and patients with IC (n = 23) or CLI (n = 23). (A) Plasma concentrations of Ang2 were significantly increased in both IC (**p < 0.01) and CLI (***p < 0.0001) patients compared with control subjects, but there was no significant difference between IC and CLI. (B) Vascular endothelial growth factor levels were significantly increased in CLI patients compared with control subjects (**p < 0.01) and IC (*p < 0.05), but there was no difference between IC and control subjects. (C) sTie2 concentrations were significantly greater in CLI patients compared with control subjects (***p < 0.0001) and IC (***p < 0.0001), but there was no difference between IC and control subjects. CLI = critical limb ischemia; IC = intermittent claudication; other abbreviations as in Figure 1.