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Figure 1 Plasma Concentrations of Ang2, VEGF, and sTie2 Are Increased in PAD

Plasma concentrations of sVEGFR-1 (A), PlGF (B), Ang2 (C), VEGF (D), and sTie2 (E) were measured in control subjects (n = 23) and patients with PAD (n = 46). Concentrations of sVEGFR-1 and PlGF were not significantly different between the 2 populations; however, Ang2 (*p < 0.0001), VEGF (*p < 0.01), and sTie2 (*p < 0.01) were significantly greater in PAD patients. Ang2 = angiopoietin-2; PAD = peripheral arterial disease; PlGF = placenta growth factor; sTie2 = soluble Tie2; sVEGFR = soluble vascular endothelial growth factor receptor; VEGF = vascular endothelial growth factor.