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Figure 2 Plaque Without Contrast-Agent Enhancement Showing Scant Neovascularization at Histology

Panel A shows a large, predominantly hypoechoic plaque, at the origin of the internal carotid artery. No plaque enhancement can be detected by contrast-enhanced ultrasound imaging (B). Panel C shows the micrograph of 1 of the sections studied of the corresponding plaque (Movat's pentachrome staining, x0.5). Panel D represents the inset in panel C. In the region nearby the fibrous cap, only a few newly formed small vessels CD31/34 positive are present (arrow, x10).