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Figure 1 Effect of GCH1 Haplotype on Plasma/Vascular BH4

The presence of the haplotype (XO or XX) was associated with significantly lower levels of plasma tetrahydrobiopterin (BH4) (A) and total biopterins (tBio) (B). A similar effect was also observed in saphenous veins (SV) (C and D) and internal mammary arteries (IMA) (E and F).