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Figure 2 Mean Change From Baseline in Urine Volume and Osmolality

(Top) Mean change from baseline in urine volume in the first 8 h after treatment administration. A dose-dependent increase in urine output was observed among the tolvaptan-treated groups. (Bottom) Mean change from baseline in urine osmolality in the first 8 h after dosing. Urine osmolality was significantly reduced by all doses of tolvaptan relative to placebo (p < 0.0001 for all tolvaptan groups vs. placebo).