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Figure 1 Relationship Between On-Treatment LDL-C Levels and Incident Cancer in the Statin and Control Arms

Each arm from each trial is considered an independent cohort of statin-treated or control individuals and is represented by an empty circle (with size proportional to each arm's weight in the meta-regressions). Note how statin cohorts (arms) are shifted toward lower on-treatment low-density lipoprotein cholesterol (LDL-C) levels, while corresponding to the same range of incident cancer rates. Note the LDL-C scale on the horizontal axis.