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Figure 4 Risk of Death by Baseline NT-proBNP and Categories of Changes Over 4 Months
Patients were divided into 4 categories according to NT-proBNP concentration at baseline and 4 months relative to a threshold of 1,078 pg/ml. A multivariate Cox proportional hazards model was used to compare the risk of death among the 4 categories of patients and by baseline NT-proBNP concentration (log-transformed) using the low
low group as a referent. The model was adjusted for clinical variables with statistically significant association to outcome (age, body mass index, serum creatinine at baseline, ischemic etiology of heart failure, New York Heart Association functional class, left ventricular ejection fraction and diameter, and prescription of digoxin and diuretics). Data are presented as hazard ratio (HR) and 95% confidence interval (CI). NT-proBNP = N-terminal pro-brain natriuretic peptide.