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Figure 5 Changes in Plaque Nuclei Number/mm² of Plaque in Response to Light, MV0611, and PDT

Blue bars represent light-only controls, green bars are drug-only controls, and brown bars represent drug and light combination. Graph A shows initial (7 days) transient reduction in all atherogenic cells/mm² of plaque followed by plaque cell repopulation by 28 days (n = 12 arteries/group). Photomicrographs show hematoxylin and eosin staining of iliac arteries at 7 and 28 days after photodynamic therapy (PDT) (B and C) versus controls (D and E). Note the loss of "foam" cells at 28 days in panel C compared with controls. Magnification x200. ***p < 0.001.