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Figure 3 Effect of PDT on Cell Depletion

(A) The effects of Miravant photosensitizer compound incubation time on cell depletion throughout entire regional plaques. Note that maximum cell depletion is observed at 8 and 24 h after injection. Also note, in rabbits killed at 3 days after photodynamic therapy (PDT), evidence of significant plaque cell apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (black) staining (B) compared with contralateral untreated control (C).