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Figure 6 Possible Effects of Renin Inhibitors on Receptor-Bound Renin and Pro-Renin

Potential sites of inhibition of the enzymatic activity and direct intracellular effects of receptor-bound renin and pro-renin. ERK1/2 = extracellular signal-regulated kinase 1/2; PAI-1 = plasminogen activator inhibitor-1; TGF-β = transforming growth factor-beta. Reprinted with permission from Nguyen (74).