Click on image to view larger version.

Figure 1 Cholesterol Biosynthesis and the Beneficial and Adverse Downstream Effects of Statin Treatment

Beneficial (gray background) and adverse (checkered background) downstream effects of statin treatment. eNOS = endothelial nitric oxide synthase; HMG-CoA = 3-hydroxy-3-methylglutaryl coenzyme A; LPS = lipopolysaccharide; NAD(P)H = nicotinamide adenine dinucleotide phosphate; NFB = nuclear factor kappa B; PI3 = phosphatidylinositol-3; PP = pyrophosphate; tRNA = transfer ribonucleic acid.