Click on image to view larger version.

Figure 2 Effects of Sirolimus on Vascular Superoxide Levels

Effects of sirolimus (Sir) exposure on vascular superoxide levels as compared to control animals (Ctr). Aortic cross-sections with DHE labeling (1 µM), which produces red fluorescence when oxidized to ethidium by superoxide. Elastic laminae in media (m) with green autofluorescence. Data are representative of n = 3 independent experiments. a = adventitia; DHE = dihydroethidine; e = endothelium; L-NAME = N^G-nitro-L-argine methyl ester.