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Figure 2 Chaperone Expression in Early and Advanced Experimental Atherosclerosis

Aortic samples from apolipoprotein E^–/– mice fed a Western diet for up to 40 weeks and a chow diet for 69 weeks. As presented in the upper panels, there is an increase in the expression of heat shock protein (HSP) 60 and HSP70 by immunohistochemistry from 3 to 20 weeks. Immunoblotting, as presented in the lower panels, confirms these findings and shows that this increase in expression is specific for lesion sites and decreases in chronic lesions of aged mice. Images used with permission of the American Heart Association (16).