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Figure 5 MMP Activity

(A) Representative results of gelatinase's activity. In the matrix metalloproteinases (MMPs) inhibitor (–) group, gelatinase's activity was generally observed in the myocardial infiltrating area in full allografts (a). However, clarithromycin (CAM) treatment markedly attenuated gelatinase's activity (b). The MMPs inhibitor (+) films show the non–gelatinase-specific activity (c and d). Scale bars = 4 mm (a to d). (B) Representative results of immunohistochemistry. Although expression of MMP-9 was observed in the infiltrating cells in nontreatment allografts (a), CAM treatment suppressed the expression (b). Scale bars = 50 µm (a and b).