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Figure 4 Mechanistic Hypothesis

(Left) Low–flow-mediated constriction (FMC) and FMD measurements during infusion of normal saline or levo-N-monomethyl arginine (L-NMMA) (8 µmol/min). Low–FMC was not modified by L-NMMA, suggesting that nitric oxide plays a lesser role in regulating resting arterial tone. *p < 0.01. (Right) Low-FMC and FMD measurements after placebo, fluconazole (150 mg orally), and aspirin (500 mg orally). Low–FMC was significantly blunted after fluconazole and aspirin. *p < 0.05. Abbreviations as in Figure 1.