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Figure 3 Protocol 3, Role of MKPs

(A) Expression of MKP-1 in adult mouse hearts, 2-year-old mouse hearts, and 2-year-old mouse hearts infused with sodium orthovanadate (NaV). *p < 0.05 versus adult. (B) Expression of phospho-ERK 1/2 in 2-year-old mouse hearts infused with NaV. p = 0.08 versus NaV + control. (C) Infarct size (expressed as a percent of the total left ventricle [LV]) in 2-year-old mouse hearts infused with NaV. *p < 0.05 versus NaV + control. All data shown as mean ± SEM. Abbreviations as in Figure 1.