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Figure 1 Cardiac Fibrosis at the Remote Zone

(Top) Representative sections from the remote zone with sirius red staining (red, magnification 400x) at 4 weeks after infarction. Collagen deposition within the left ventricle is reduced after administering either nicorandil (Nic) or pinacidil (Pin). The line length corresponds to 50 µm. (Bottom) Left ventricular collagen area fraction (%). Each column and bar represents mean ± standard deviation. *p < 0.007 compared with vehicle-, glibenclamide (Glib)-, Nic + Glib-, and Pin + Glib-treated groups. (A) Sham; (B) vehicle; (C) Nic; (D) Pin; (E) Glib; (F) Nic + Glib; (G) Pin + Glib; (H) rapamycin (Rap); (I) Rap + Nic; (J) Rap + Pin.