Click on image to view larger version.

Figure 7 Relative Expression Levels of HIF Pathway mRNA

(A) The expression ratio determined between 9 early and 6 stable lesions by microarray analysis was significantly different for HIF1, VEGF, GLUT3, and HK2. *p < 0.01; **p < 0.001; ***p < 0.00001. (B) Quantitative reverse transcription polymerase chain reaction was used to compare the expression ratio between 5 early and 5 stable lesions collected at autopsy (*p < 0.05) and (C) between 4 stable and 5 thrombus-containing lesions collected at surgery. GLUT = glucose transporter; HK = hexokinase; mRNA = messenger ribonucleic acid; other abbreviations as in Figure 2.