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Figure 2


Figure 2 Hypoxia Colocalizes With CD68, HIF, and VEGF

(A) Hypoxia detected by pimonidazole immunoreactivity in human carotid atherosclerosis. Serial sections show colocalization with CD68-positive macrophages (B), HIF1{alpha} (C), and VEGF (D). (E) The immunoreactivity score of CD68, HIF1{alpha}, and VEGF is increased when hypoxia is present (solid bars) versus absent (open bars) in human carotid atherosclerosis (*p < 0.05). HIF = hypoxia-inducible transcription factor; VEGF = vascular endothelial growth factor.